Results 101 to 110 of about 21,716,016 (301)

Investigation of Natural Effective Gamma Dose Rates case study: Ardabil Province in Iran [PDF]

Gamma rays pose enough energy to form charged particles and adversely affect human health. Since, the external exposure of human beings to natural environmental gamma radiation normally exceeds that from all man-made sources combined, natural background ...
زیوری, سحر, صادقی, هادی, Sahar Zivari, Soheila Rahimzadeh, حضرتی, صادق, رحیم زاده, سهیلا, Manouchehr Barak, Abbas Baghi, Hadi Sadeghi, براک, منوچهر, Sadegh Hazrati, نقی زاده باقی, عباس   +11 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Outcomes of patients with localized prostate cancer treated with combined external beam radiotherapy and high-dose-rate brachytherapy boost: A single-center retrospective study

Forum of Clinical Oncology
Temporary prostate brachytherapy, in combination with external beam radiotherapy (EBRT), is an established and evolving treatment technique for non-metastatic, intermediate and high-risk prostate cancer.
Rothwell David, Sousa Joana Costa, Magalhães Ricardo, Guimarães Irina, Pires Beatriz, Barros João Pedro, Leite Regina, Rodrigues Mónica, Alves Carla, Miranda Cristina, Melo Gilberto, Alves Paula   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High Dose Rate Intracavitary Afterloading Techniques [PDF]

Acta Radiologica. Diagnosis, 1971
K W, Beckman, O, Odelberg-Johnson, K J, Vikterlöf   +2 more
openaire   +2 more sources

Unexpected lower biochemical control of high-dose-rate brachytherapy boost than low-dose-rate brachytherapy boost for clinically localized prostate cancer

Clinical and Translational Radiation Oncology, 2020
Hideya Yamazaki, Koji Masui, Gen Suzuki, Ken Yoshida   +3 more
doaj   +1 more source

Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations

Clinical and Translational Radiation Oncology
The tissue sparing of ultra-high dose rate irradiation has been partially observed in vitro while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids ...
Rutger Jan Cornelis de Koster, Jeremy Putra Gunawan, Hans Peters, Johan Bussink, Lara Barazzuol, Marc-Jan van Goethem, Alexander Gerbershagen, Robert Paul Coppes, Stefan Both   +8 more
doaj   +1 more source

Results and complications of high dose rate and low dose rate brachytherapy in carcinoma of the cervix: Cerrahpasa experience

, 2003
Purpose: To evaluate the results and complications of treatment with high dose rate (HDR) compared to low dose rate (LDR) brachytherapy in cervical ...
Atkovar, G, Uzel, R, Okkan, S, Sahinler, I, Koca, A, Koksal, S, Dincbas, FO, Turkan, S, Sahinler, İsmet, Koksal, Serdar Selçuk   +9 more
core   +1 more source