Results 111 to 120 of about 21,716,016 (301)

Non-melanoma skin cancer treated with high-dose-rate brachytherapy: a review of literature [PDF]

, 2016
Purpose: The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. There are different treatment options and surgical excision is the most frequent treatment due to its low rates of recurrence.
Durim Delishaj, Md1, Rembielak, Agata, Morganti, Riccardo, Md,, Phd,, Laliscia, Concetta, Manfredi, Bruno, ORLANDI, FRANCESCA, URSINO, STEFANO, PAIAR, FABIOLA, Fabrini, Maria Grazia, Pasqualetti, Francesco, Rembielak, A., Manfredi, B., Pasqualetti, F., Paiar, F., Laliscia, C., Morganti, R., Concetta Laliscia, Francesco Pasqualetti, Ursino, S, Ursino, S., Francesca Orlandi, Laliscia, C, Paiar, F, Agata Rembielak, Maria Grazia Fabrini, Morganti, R, Bruno Manfredi, Stefano Ursino, DELISHAJ, DURIM, Durim Delishaj, Manfredi, B, Delishaj, D, Fabiola Paiar, Delishaj, D., Riccardo Morganti, Orlandi, F., Pasqualetti, F, Orlandi, F, Fabrini, M.G., Fabrini, Maria G   +41 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ultra-High-Dose Rate FLASH Radiotherapy

Ultra-High-Dose Rate (UHDR) FLASH radiotherapy is an emerging modality that has demonstrated the potential to revolutionize cancer treatment by delivering radiation doses at rates several orders of magnitude higher than conventional therapies. This chapter offers a comprehensive overview of the FLASH effect, a phenomenon wherein ultra-rapid dose ...
Gaia Franciosini, Lucia Giuliano, Luigi Palumbo, Vincenzo Patera   +3 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Low-dose-rate induces more severe cognitive impairment than high-dose-rate in rats exposed to chronic low-dose γ-radiation

Frontiers in Public Health
BackgroundOwing to the long penetration depth of gamma (γ)-rays, individuals working in ionizing radiation environments are chronically exposed to low-dose γ-radiation, resulting in cognitive changes.
Tianbao Ma, Tianbao Ma, Kexian Li, Wenjuan Sang, Xingyu Liu, Qun Luo, Ye Peng, Mingxing Wang, Xiu Luo, Jingjing Fang, Haijun Wang, Tao Wang, Changjing Zuo, Changjing Zuo   +13 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

High-dose-rate intraluminal brachytherapy prior to external radiochemotherapy in locally advanced esophageal cancer: preliminary results

, 2017
Purpose: Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance.
Reza Ghalehtaki, Borna Farazmand, Mohammad Babaei, Nezhat Khanjani, Afsaneh Maddah Safaei, Ebrahim Esmati   +5 more
core   +1 more source