Results 181 to 190 of about 21,716,016 (301)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Development of a low-cost 3D-printed phantom for end-to-end testing of model-based dose calculation algorithms (MBDCAs) in high-dose-rate (HDR) brachytherapy. [PDF]

J Appl Clin Med Phys
Grace S, Wang L, Cao Y, Huang L.
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

High Dose Rate Brachytherapy(HDR BT) in Organ Confined Prostate Cancer

Apollo Medicine, 2008
P Mahadev, L S Ravishankar, P G G Kurup, V Murali, Jayraj , Bhagyam   +5 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

High-dose-rate monotherapy for localised prostate Cancer: A two-implant approach with median 13 years follow-up. [PDF]

Clin Transl Radiat Oncol
Best C, Spier V, Baltas D, Ackermann H, Rödel C, Zamboglou N, Tselis N.   +6 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Endobronchial High-Dose-Rate Brachytherapy for Posttransplant-Associated Bronchial Stenosis: Extended Follow-up of Pulmonary Function and Subsequent Procedures. [PDF]

Adv Radiat Oncol
Schaar DA, Yohannes A, Groszkiewicz A, Iheagwara U, Johnson BA, Schuchert M, Li F, Houser C, Doraisamy E, Kim H, Burton SA, Vargo JA.   +11 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Ultra-high dose rate dependent modeling of plasmid DNA damage with TOPAS-nBio. [PDF]

Phys Med Biol
Masilela TAM, D-Kondo JN, Shin WG, Rezaee M, LaVerne JA, Paganetti H, Faddegon B, Schuemann J, Ramos-Méndez J.   +8 more
europepmc   +1 more source