Results 121 to 130 of about 31,917,810 (358)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The efficiency of financial markets with high inflation [PDF]

, 1994
In a two period general equilibrium model with incomplete asset markets, it is shown that the contraction of nominal financial markets that occurs during high inflations can result from the variability of the future rate of inflation and from large ...
Neumeyer, Pablo Andrés
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Advancements in Genetic Marker Exploration for Livestock Vertebral Traits with a Focus on China

Animals
In livestock breeding, the number of vertebrae has gained significant attention due to its impact on carcass quality and quantity. Variations in vertebral traits have been observed across different animal species and breeds, with a strong correlation to ...
Muhammad Zahoor Khan, Wenting Chen, Bingjian Huang, Xiaotong Liu, Xinrui Wang, Yihong Liu, Wenqiong Chai, Changfa Wang   +7 more
doaj   +1 more source

Simulation and experimental research of hydraulic pressure and intake valve lift on a fully hydraulic variable valve system for a spark-ignition engine

Advances in Mechanical Engineering, 2018
A fully hydraulic variable valve system based on spark-ignition engine BJ486EQ is introduced in this article, which can provide fully variable valve lifts, valve timing, and valve opening duration.
Fei Chen, Yingjie Chang, Zongfa Xie, Kaiyu Zhang, Tingting Sun, Xiaorui Li, Yuzhen Huang   +6 more
doaj   +1 more source

Noise-free high-efficiency photon-number-resolving detectors

, 2005
High-efficiency optical detectors that can determine the number of photons in a pulse of monochromatic light have applications in a variety of physics studies, including post-selection-based entanglement protocols for linear optics quantum computing and ...
Aaron Miller, Adriana Lita, D. Achilles, Danna Rosenberg, N. Lutkenhaus, R. Engstrom, Sae Nam, W. G. Oldham   +7 more
core   +1 more source

Giant energy density and high efficiency achieved in bismuth ferrite-based film capacitors via domain engineering

Nature Communications, 2018
Developing high-performance film dielectrics for capacitive energy storage has been a great challenge for modern electrical devices. Despite good results obtained in lead titanate-based dielectrics, lead-free alternatives are strongly desirable due to ...
Haowei Pan, Jing Ma, Ji Ma, Qinghua Zhang, Xiaozhi Liu, Bo Guan, L. Gu, Xin Zhang, Yujun Zhang, Liangliang Li, Yang Shen, Yuanhua Lin, C. Nan   +12 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Surface Hardening of Massive Steel Products in the Low-pressure Glow Discharge Plasma

Technologies, 2019
A process vacuum chamber is filled with a homogeneous plasma of glow discharge with electrostatic electron confinement, which is used for surface hardening of massive products.
Sergey Grigoriev, Alexander Metel, Marina Volosova, Yury Melnik, Htet A. Ney, Enver Mustafaev   +5 more
doaj   +1 more source