Results 51 to 60 of about 16,800,727 (310)

ZG02 Improved Hepatic Glucose Metabolism and Insulin Sensitivity via Activation of AMPK/Sirt1 Signaling Pathways in a High-fat Diet/Streptozotocin-induced Type 2 Diabetes Model

Diabetes, Metabolic Syndrome and Obesity, 2020
Yi Zhang,1– 3 Bo Zhou,1,2,4 Min Wen,1 Mi Hu,1 Jin-Gang Peng,1– 3 Ying Wang,3 Lin-Lin Fan,1– 3 Lei Tang1– 3 1College of Basic Medical Sciences, Guizhou Medical University, Guizhou, 550004, People’s Republic of China ...
Zhang Y, Zhou B, Wen M, Hu M, Peng JG, Wang Y, Fan LL, Tang L   +7 more
doaj  

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

High impact activity is related to lean but not to fat mass: findings from a population-based study in adolescents [PDF]

, 2012
Background: Objective measures of physical activity calibrated against energy expenditure may have limited utility in studying relationships with musculoskeletal phenotypes.
Rittweger, Jörn, Deere, Kevin, Tobias, Jonathan H, Davey Smith, George, Tobias, Jon, Sayers, Adrian   +5 more
core   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Alternate-day fat diet and exenatide modulate the brain leptin JAK2/STAT3/SOCS3 pathway in a fat diet-induced obesity and insulin resistance mouse model

Archives of Medical Science, 2023
Introduction Obesity is one of the most burdensome health problems and is closely linked to leptin resistance. The study examined whether an alternate-day high-fat diet (ADF) and/or GLP-1 agonist (exenatide) modulate brain leptin resistance caused by a ...
Mona K. Tawfik, Dahlia I. Badran, Mohammed M. Keshawy, Samy Makary, Mohamed Abdo   +4 more
doaj   +1 more source

High Carbohydrate and High Fat Diets

Experimental Biology and Medicine, 1933
SummaryThe glucose tolerance was not significantly altered by a very high carbohydrate intake, over a period of 7 days. After 7 days on a high fat diet, the response to the glucose tolerance test was typical of diabetes mellitus; the tolerance fapidly returned to the usual type, after return to the balanced diet.
E. M. Greisheimer, E. Goldsworthy, G. Thomas   +2 more
openaire   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice

, 2012
Aims: to determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring.Methods: female C57BL6J mice were fed an obesogenic high fat diet (HF, 45%
Geraldine F Clough, Clough, G.F., Torrens Christopher, Mann, Giovanni E.; id_orcid, Hanson Mark A., Mann Giovanni E., Kimberley D Bruce, Cagampang Felino R. A., Christopher Torrens (114420), Mann, G.E., Ethirajan Priya, Richard C M Siow, Geraldine F. Clough (114433), Byrne Christopher D., Christopher D. Byrne (114429), Siow, Richard C. M.; id_orcid, Felino R. A. Cagampang (114423), Ethirajan, Priya, Cagampang, Felino R. A., Mark A. Hanson (114427), Bruce, K.D., Byrne, Christopher D., Richard C. M. Siow (114425), Giovanni E. Mann (114431), Priya Ethirajan, Mark A Hanson, Kimberley D. Bruce (114422), Bruce Kimberley D., Siow Richard C. M., Christopher D Byrne, Ethirajan, P., Priya Ethirajan (114421), Clough Geraldine F., Torrens, Christopher, Felino R A Cagampang, Giovanni E Mann, Hanson, Mark A., Christopher Torrens, Bruce, Kimberley D., Clough, Geraldine F., Siow, R.C., Cagampang, F.R.   +41 more
core   +1 more source