Results 61 to 70 of about 16,800,727 (310)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila [PDF]

, 2022
High-fat diet (HFD)-induced obesity has become the major risk factor for the development of cardiovascular diseases, but the underlying mechanisms remain poorly understood.
Bai, Hua, Liu, Peiduo, Chang, Kai, Requejo, Guillermo   +3 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Enhanced mitochondrial superoxide scavenging does not Improve muscle insulin action in the high fat-fed mouse [PDF]

, 2015
Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or transgenically expressing catalase
Jeffrey S. Bonner¤b, Daniel S. Lark, Wasserman David H., Mary E Lustig, Darrell Neufer, David H. Wasserman, Lark Daniel S., Lustig, Mary E., Freyja D James, Bonner, Jeffrey S, Kang Li, James Freyja D., NC DOCKS at East Carolina University, Lark, Daniel Stephen, P Darrell Neufer, Freyja D. James, Lark, Daniel S., Wasserman, David H., Kang, Li, Bonner Jeffrey S., Daniel S Lark, Lustig Mary E., Bonner, Jeffrey S., Neufer P. Darrell, Mary E. Lustig, Neufer, Darrell, Neufer, P. Darrell, David H Wasserman, James, Freyja D., Jeffrey S Bonner, Li Kang   +30 more
core   +2 more sources

Impact of the rs822393 Variant on Adiponectin Levels and Metabolic Parameters after Weight Loss Secondary to a High-Fat Hypocaloric Diet with Mediterranean Pattern

Lifestyle Genomics
Introduction: The effects of the rs822393 variant of ADIPOQ gene on metabolic parameters such as insulin resistance and adiponectin levels following weight loss through dietary intervention are still uncertain.
David Primo, Olatz Izaola, Juan Jose Lopez Gomez, Daniel Rico, Daniel A. de Luis   +4 more
doaj   +1 more source

Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

Journal of Lipid Research, 2011
Acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) is thought to be crucial for dietary fat absorption. Indeed, mice lacking the enzyme (Mogat2−/−) are resistant to obesity and other metabolic disorders induced by high-fat feeding.
David W. Nelson, Yu Gao, Nicole M. Spencer, Taylor Banh, Chi-Liang Eric Yen   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

How the brain represents the reward value of fat in the mouth. [PDF]

, 2009
The palatability and pleasantness of the sensory properties of foods drive food selection and intake and may contribute to overeating and obesity. Oral fat texture can make food palatable and pleasant.
Parris, Benjamin, De Souza, Arun, Rolls, Edmund T., Grabenhorst, Fabian   +3 more
core   +1 more source

A Short-Term High-Fat Diet Improved the Survival of Fat Grafts in Mice by Promoting Macrophage Infiltration and Angiogenesis

Frontiers in Cell and Developmental Biology, 2022
Background: Adipose tissue is an ideal filler material that is widely used for soft tissue defects. But the low survival rate and complications associated with such grafts pose a serious challenge, which limits their clinical application.
Xingtang Niu, Zhuhao Lai, Xihang Chen, Feng Lu, Jianhua Gao, Yi Yuan   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source