Results 71 to 80 of about 16,800,727 (310)
Experimental PhysiologyIndependent effects of maternal obesogenic diets on offspring outcomes are acknowledged, but data on paternal and combined maternal–paternal obesity remain limited.
Khurram Jahangir Toor +8 more
doaj +1 more source
Paternal allele influences high fat diet-induced obesity. [PDF]
PLoS ONE, 2014 C57BL/6J (B6) mice are susceptible to high-fat diet (HFD)-induced obesity and have been used in metabolism research for many decades. However, the genetic component of HFD-induced obesity has not yet been elucidated.
Sumiyo Morita +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2019 Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes.
Bhandarkar, Nikhil S. +3 more
core +1 more source
Why there is a Need to Priortise Regulation of Ultra-processed Foods and HFSS Foods in India?
Preventive Medicine: Research & ReviewsIncidence of non-communicable diseases (NCDs) such as diabetes and obesity is on the rise worldwide. Rising consumption of ultra-processed food (UPF) products or those high in fats, sugars or salt also called junk foods contributes to this grave ...
Arun Gupta
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
AnimalsControlling dry matter intake (DMI) is one strategy to reduce feed costs and increase efficiency. Including fat at a high concentrate level can increase the energy density of diets fed to ruminants, thus reducing DMI further.
Saad M. Hussein +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Efficiency of fat deposition from nonstarch polysaccharides, starch and unsaturated fat in pig [PDF]
, 2009 The aim was to evaluate under protein-limiting conditions the effect of different supplemental energy sources: fermentable NSP (fNSP), digestible starch (dStarch) and digestible unsaturated fat (dUFA), on marginal efficiency of fat deposition and ...
Halas, V. +9 more
core +1 more source