Results 51 to 60 of about 862,398 (311)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A way to obtain highly ordered and thermally stable crystalline In–Ga–O (IGO) thin films is reported by atomic layer deposition with novel bulky dimethyl[N‐(tert‐butyl)−2‐methoxy‐2‐methylpropan‐1‐amine] gallium precursor.
Seong‐Hwan Ryu +3 more
doaj +1 more source
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Job Mobility and Wage Mobility of High- and Low-paid Workers
Studies have shown that voluntary job-to-job changes have a positive effect on wage growth. This paper argues that the impact of a job change on wage mobility depends on the position in the wage distribution. Using panel data from the UK and Germany, we show that a change of employer results into a wage increase only for the low paid workers.
Pavlopoulos, Dimitris +3 more
openaire +4 more sources
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Performance Analysis of OTFS Framework Over Wideband Time-Varying Channels
Orthogonal Time Frequency Space (OTFS) modulation has garnered significant attention for its robustness in high-mobility communication scenarios. Existing research predominantly focuses on narrowband time-varying channels, where Doppler effects manifest ...
Ziqiang Gao +8 more
doaj +1 more source
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
In the evolving landscape of next-generation wireless networks, ensuring seamless mobility and high-quality service delivery for millions of devices and end users in dynamic scenarios, where the speed of a wireless device keeps changing with time, is ...
Yahya S. Junejo +3 more
doaj +1 more source
High mobility emissive organic semiconductor [PDF]
The integration of high charge carrier mobility and high luminescence in an organic semiconductor is challenging. However, there is need of such materials for organic light-emitting transistors and organic electrically pumped lasers. Here we show a novel organic semiconductor, 2,6-diphenylanthracene (DPA), which exhibits not only high emission with ...
Liu, Jie +10 more
openaire +4 more sources

