Results 221 to 230 of about 204,374 (297)

Integrating image-based phenotyping and GWAS to map resistance to spittlebug nymphs in interspecific Urochloa grasses. [PDF]

G3 (Bethesda)
Espitia-Buitrago P, Perea C, Mejia-Medina JC, Hernández LM, Castiblanco V, Ryan C, De Vega JJ, Jauregui RN.   +7 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Understanding the Impact of Single-Helical Maize Amylose on Steamed Bun Hardness Enhancement. [PDF]

Foods
Yu J, Zhang Z, Ran S, Li X, Wang C, Guo J, Lian X.   +6 more
europepmc   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Impact of solvent forces and broken symmetry on the assembly of designed proteins at a liquid-solid interface. [PDF]

Nat Commun
Yadav Schmid S, Helfrecht B, Stegmann A, Legg BA, Pyles H, Chen J, Edison JR, Ziatdinov M, Preisler Z, Dollar O, Whitelam S, Kalinin S, Baker D, Mundy CJ, Zhang S, De Yoreo JJ.   +15 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

A Novel Signaling Driven by the Stem Cell Marker ALDH1A3 Promotes Glioblastoma Cell Mobility. [PDF]

Cells
Chen ZR, Chen Z, Dong Q, Will R, Busch MA, Dünker N, Dammann P, Sure U, Zhu Y.   +8 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Low-resolution FAIMS for increased peptide coverage in low-load and single-cell proteomics. [PDF]

Sci Rep
Hoch DG, Belford M, Heil LR, Mechtler K, Matzinger M.   +4 more
europepmc   +1 more source