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High-mobility-group proteins and cancer?an emerging link [PDF]
Journal of Cancer Research and Clinical Oncology, 1997 In the last few years, considerable interest has been generated in the role of high-mobility-group (HMG) proteins, and HMG box proteins generally, in cancer development and therapy. These proteins were discovered in the early 1970s (Goodwin et al. 1973) as a group of nonhistone proteins.
V, Wunderlich, M, Böttger
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High mobility group proteins of Saccharomyces cerevisiae
Biochemistry, 1980The yeast Saccharomyces cerevisiae contains four proteins having amino acid compositions typical of the high mobility group (HMG) proteins. Three of these are eluted from chromatin by 0.35 M NaCl; one is not, but it is eluted by 0.25 N HCl. It follows that HMGs cannot, in general, be defined by extractability criteria.
S, Weber, I, Isenberg
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The high mobility group proteins and transcribed nucleosomes
Cell Biology International Reports, 1981Monomer nucleosomes released from nuclei during brief micrococcal nuclease digestions are enriched in transcribed sequences (Bloom and Anderson, 1978). These nucleosomes are depleted in H1 and enriched in three high mobility group proteins HMG14, HMG17 and another HMG-like protein.
C G, Mathew +3 more
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Discrete proteolytic cleavage of High Mobility Group proteins
Biochemical and Biophysical Research Communications, 1979Abstract Chromatographic fractionation on CM-Sephadex of a 0.35 M NaCl extract from calf thymus chromatin reveals the presence of a High Mobility Group (HMG) protein which comigrates electrophoretically with HMG-17. Further amino acid analysis and partial sequence determination suggest that this protein is a proteolytic degradation product of either ...
R, Sterner, G, Vidali, V G, Allfrey
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An alternative procedure for the isolation of high mobility group proteins
Analytical Biochemistry, 1981Abstract A new procedure for the isolation of high mobility group proteins from chromatin is described. The method utilizes ammonium sulfate for both extraction and selective precipitation of the HMG proteins. It is rapid, simple, and provides high yields.
B S, Bhullar, E P, Candido
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Characterization of human SMARCE1r high-mobility-group protein
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002The high-mobility-group (HMG) proteins are chromatin-associated proteins that are common to all higher organisms. They bind DNA in a sequence-specific or non-sequence-specific way to induce DNA bending, and regulate chromatin function and gene expression. Here we report the characterization of an HMG box-containing gene, designated human Smarce1r gene.
Young Mi, Lee +4 more
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A study of the localization of high mobility group proteins in chromatin
Canadian Journal of Biochemistry, 1978High mobility group (HMG) proteins from fetal calf thymus and mouse brain chromatin were purified and compared electrophoretically. The four major HMG proteins characteristic of fetal calf thymus chromatin (HMG's 1, 2, 14, and 17) were also found to be present in mouse brain chromatin.Nuclei from these two eucaryotic tissues were digested with DNase I
W B, Levy, G H, Dixon
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High-mobility group box 1 protein in endophthalmitis
Graefe's Archive for Clinical and Experimental Ophthalmology, 2008High-mobility group box 1 protein (HMGB1) is recently described as a late mediator of lethal endotoxemia with proinflammatory cytokine-like properties. The purpose of this study was to determine whether HMGB1 is involved in endophthalmitis.In this retrospective case-control study, vitreous levels of HMGB1 were measured by an enzyme-linked immunosorbent
Noboru, Arimura +4 more
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High Mobility Group Box 1: An Immune-regulatory Protein
Current Gene Therapy, 2019High mobility group box 1 (HMGB1) presents in almost all somatic cells as a component of the cell nucleus. It is necessary for transcription regulation during cell development. Recent studies indicate that extracellular HMGB1, coming from necrotic cells or activated immune cells, triggers inflammatory response whereas intracellular HMGB1 controls the ...
Jingjing Zhao +3 more
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High mobility Group I-C protein in astrocytoma and glioblastoma
Pathology - Research and Practice, 2004High mobility group I-C (HMGI-C) protein is a non-histone DNA-binding factor that organizes active chromatin. This protein is expressed during the limited phase of embryonic development and may regulate the expression of genes critical for embryonic cell growth and differentiation.
Takuya, Akai +8 more
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