Results 41 to 50 of about 755,147 (291)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of Phytoestrogens by High Performance Liquid Chromatography [PDF]

, 1999
Phytoestrogens are biochemicals synthesized in plants which mimic steroidal estrogen activity in mammals. Analysis of these compounds in the legumes which produce them and in body fluids is important to the study of their physiological effects.
Grippo, Anne A., Rougeau, Benjamin L., Wyatt, William V., Xie, Yan   +3 more
core   +1 more source

Neural networks in high-performance liquid chromatography optimization:Response surface modeling [PDF]

, 1996
The usefulness of artificial neural networks for response surface modeling in HPLC optimization is compared with (non-)linear regression methods. The number of hidden nodes is optimized by a lateral inhibition method.
Coenegracht, P.M J, Metting, H.J
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Studi Degradasi Sediaan Infus Ciprofloksasin Menggunakan High Performance Liquid Chromatography

Jurnal Farmasi Sains dan Praktis, 2016
Penelitian ini menggambarkan perlakuan degradasi infus ciprofloksasin yang dikondisikan dengan pemanasan, penambahan asam dan basa. Produk degradasi dianalisis menggunaan perangkat HPLC merk Waters e2695 Separations, kolom SunFireTM C18, detektor PDA ...
Bekti Nugraheni
doaj   +1 more source

ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients

Журнал органічної та фармацевтичної хімії, 2020
Aim. To determine the fragmentation pathways of eight 1,2,4-triazole-3-thiones, which are intermediate products in the synthesis of active pharmaceutical ingredients of potential and registered pharmaceutical formulations. Results and discussion. HPLC-
Borys O. Varynskyi, Andriy G. Kaplaushenko   +1 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Hemoglonbin Typing by High Performance Liquid Chromatography

Journal of Associated Medical Sciences, 2015
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Thanusak Tatu, P Kaidkaseam, P Hathirat
doaj  

Chemical components analysis of handmade alcoholic beverages with special focus on psychoactive drugs as adulterants

MethodsX
Handmade alcoholic beverages are produced in clandestine laboratories. There are reports concerning the of counterfeit alcoholic beverages adulterated with psychoactive drugs.
Morvarid Sadat Miri, Dariush Badakhshan, Maryam Akhgari, Masoud Ghadipasha   +3 more
doaj   +1 more source

Chromatographic analysis of wheatgrass extracts

Journal of Pharmacy and Bioallied Sciences, 2015
Aim: Wheatgrass (WG) is the shoot of Triticum aestivum Linn. belongs to the family Gramineae, and possess high chlorophyll content and essential vitamins, minerals, vital enzymes, amino acids, dietary fibers etc., It has been shown to possess anti-cancer,
Masood Shah Khan, Rabea Parveen, Kshipra Mishra, Rajkumar Tulsawani, Sayeed Ahmad   +4 more
doaj   +1 more source