Results 251 to 260 of about 280,529 (308)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

open access: yesAdvanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins   +9 more
wiley   +1 more source

Bioinspired Mechanically Robust Organic–Inorganic Hybridized Bio‐Adhesives With up to 50% Inorganic Components by Bi‐Continuous Phase Engineering

open access: yesAdvanced Functional Materials, EarlyView.
A robust plant protein adhesive was prepared by fabricating a bi‐continuous organic–inorganic hybrid structure. Compared with traditional organic–inorganic hybrid adhesives, the addition amount of inorganic phase is increased from 0.2%–3.0% to 50%, and the strength and toughness are increased by 6 and 121 times, respectively.
Zheng Liu   +10 more
wiley   +1 more source

Lysosphingolipid Quantitation in Plasma and Dried-Blood Spots Using Targeted High-Resolution Mass Spectrometry. [PDF]

open access: yesJ Clin Lab Anal
Ducatez F   +17 more
europepmc   +1 more source

Organ-resolved lipid mapping in <i>Steatoda nobilis</i> spider model using high-resolution mass spectrometry imaging and Kendrick mass defect analysis. [PDF]

open access: yesFront Chem
Redureau D   +11 more
europepmc   +1 more source

High-resolution mass spectrometry for glycoproteomics

Bioanalysis, 2023
Tweetable abstract Bottom-up glycoproteomics combined with top-down strategy allows direct analysis of glycoform-mapped glycosylation and its glycans by high-resolution mass spectrometry.
Siyue Bo   +5 more
openaire   +2 more sources

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