Results 271 to 280 of about 280,529 (308)

Proteotyping of the Parainfluenza Virus with High-Resolution Mass Spectrometry

Analytical Chemistry, 2013
Parainfluenza viruses (PIVs) are one of the most common causes of respiratory tract infections in children and can be life-threatening when the airway becomes obstructed. Infection results in a spectrum of respiratory disease symptoms that makes diagnosis difficult.
An P, Nguyen, Kevin M, Downard
openaire   +2 more sources

Tissue Analysis with High-Resolution Imaging Mass Spectrometry

2009
Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers.
Altelaar, A.F.M., Heeren, R.M.A.
openaire   +3 more sources

Yeast Expression Proteomics by High-Resolution Mass Spectrometry

2010
Comprehensive analysis of yeast as a model system requires to reliably determine its composition. Systematic approaches to globally determine the abundance of RNAs have existed for more than a decade and measurements of mRNAs are widely used as proxies for detecting changes in protein abundance.
Walther, Tobias C, Olsen, Jesper Velgaard, Mann, Matthias   +2 more
openaire   +4 more sources

High-resolution mass spectrometry for thymosins detection and characterization

Expert Opinion on Biological Therapy, 2015
The aim of this study was to characterize β and α thymosins and their proteoforms in various tissues and bodily fluids by mass spectrometry and to look at their association with a wide variety of pathologies.A top-down proteomic platform based on high-performance liquid chromatography (HPLC) coupled to high-resolution LTQ-Orbitrap mass spectrometry (MS)
CABRAS, TIZIANA, Iavarone, Federica, Martelli, Claudia, Delfino, Daniela, Rossetti, Diana Valeria, Inserra, Ilaria, MANCONI, BARBARA, Desiderio, Claudia, MESSANA, IRENE, Hannappel, Ewald, FAA, GAVINO, Castagnola, Massimo   +11 more
openaire   +4 more sources

Signal Detection in High-Resolution Mass Spectrometry Data

Journal of Proteome Research, 2008
Mass spectrometry data from high-resolution time-of-flight instruments often contain a vast number of noninformative background-ion peaks whose signal is similar to that of peptide peaks. Consequently, seeking peptide signal in these spectra based on a signal-to-noise ratio will remove signal peaks as well as noise.
Dale F, McLerran, Ziding, Feng, O John, Semmes, Lisa, Cazares, Timothy W, Randolph   +4 more
openaire   +2 more sources

Precision of fragmentation patterns in high-resolution mass spectrometry

Talanta, 1972
The effect of controlling the temperature of the ion source of a high-resolution mass spectrometer is to increase the confidence in mass spectral pattern coefficients of saturated molecules. Results are presented for both controlled and uncontrolled ion-source temperatures.
W F, Brown, I P, Fisher
openaire   +2 more sources

High-resolution tandem mass spectrometry of carbonic anhydrase

Analytical Chemistry, 1994
Electrospray ionization of carbonic anhydrase with ion dissociation yields a mass spectrum from which the masses of > 100 isotopic clusters are determined accurately, with the number of charges assigned directly from resolved isotopic peaks. Of these clusters, 80% correspond to fragmentation at or near the amino acid proline. The masses of combinations
M W, Senko, S C, Beu, F W, McLafferty
openaire   +2 more sources

Determination of oligonucleotide deamination by high resolution mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2019
A novel analytical approach capable of measuring deaminated degradation products of oligonucleotide therapeutics is described. The method employs high-resolution mass spectrometry to assess the shift in isotopic distribution that accompanies deamination. Isotopic Distribution Factors (IDF), derived directly from the peak heights of the isotopic pattern,
Claus, Rentel, Jaimie, DaCosta, Stilianos, Roussis, Jonathan, Chan, Daniel, Capaldi, Bao, Mai   +5 more
openaire   +2 more sources

High-Resolution Mass Spectrometry for Untargeted Drug Screening

2016
While gas chromatography-mass spectrometry (GC/MS) continues to be the forensic standard for toxicology, liquid chromatography coupled to tandem MS offers significant operational advantages for targeted confirmatory analysis. LC-high-resolution (HR)-MS has recently been available that offers advantages for untargeted analysis.
Alan H B, Wu, Jennifer, Colby
openaire   +2 more sources

HIGH RESOLUTION MASS SPECTROMETRY IN LIPIDOMICS

Mass Spectrometry Reviews, 2021
Thomas Züllig, Harald Köfeler
exaly