Results 61 to 70 of about 280,529 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Determination of Synthetic Cathinones in Urine and Oral Fluid by Liquid Chromatography High-Resolution Mass Spectrometry and Low-Resolution Mass Spectrometry: A Method Comparison

Separations, 2020
Synthetic cathinones have become very popular recreational drugs. Therefore, determining them in biological samples is now a matter of concern. In recent years, different methods that have been developed can determine these drugs at low-concentration ...
Sergi Pascual-Caro, Francesc Borrull, Carme Aguilar, Marta Calull   +3 more
doaj   +1 more source

Innovative solutions for enhanced illicit drugs profiling using comprehensive two-dimensional gas chromatography and mass spectrometry technologies [PDF]

, 2014
This project aimed to determine whether comprehensive two-dimensional gas chromatography is suitable for routine use in a forensic laboratory for profiling illicit substances.
Philip Marriot, Blagoj Mitrevski
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Analytic Correlation Filtration: A New Tool to Reduce Analytical Complexity of Metabolomic Datasets

Metabolites, 2019
Metabolomics generates massive and complex data. Redundant different analytical species and the high degree of correlation in datasets is a constraint for the use of data mining/statistical methods and interpretation.
Stephanie Monnerie, Melanie Petera, Bernard Lyan, Pierrette Gaudreau, Blandine Comte, Estelle Pujos-Guillot   +5 more
doaj   +1 more source

High-resolution mass spectrometry for detecting Acetylcholine in Arabidopsis [PDF]

Plant Signaling & Behavior, 2015
Acetylcholine (ACh) was first identified a century ago, and has long been known as a neurotransmitter in animals. However, it has been shown recently that the occurrence of ACh is widespread among various non-animal species including higher plants. Although previous reports suggest that various plant species are capable of responding to exogenously ...
Jun, Murata, Takehiro, Watanabe, Kohtaro, Sugahara, Tohru, Yamagaki, Toshio, Takahashi   +4 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

An Actionable Annotation Scoring Framework for Gas Chromatography - High Resolution Mass Spectrometry (GCHRMS)

, 2022
Omics-based technologies have enabled comprehensive characterization of our exposure to environmental chemicals (exposome) as well as assessment of the corresponding biological responses at the molecular level (e.g., metabolome, lipidome, proteome, and ...
Joseph, Okeme, Paul, Stelben, Matthew, Paige, Hongyu, Xie, Stefano, Papazian, Thanh, Wang, Dinesh, Barupal, Pawel, Rostkowski, Dean, Jones, Gary, Miller, Doug, Walker, Jeremy , Koelmel, John, Bowden, Xin, Hu, Vladimir, Nikiforov, Jon, Martin, Katherine, Manz, Elliott, Price, Kurt , Pennell, Krystal, Pollitt, Elizabeth, Lin, Yunjia, Lai   +21 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging

, 2013
Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources.
Robinson, E.W., Kiss, A., Leach, F.E., Paša-Tolić, L., Heeren, R.M.A., Smith, D.F.   +5 more
core   +2 more sources