Results 51 to 60 of about 846,698 (293)
High-Resolution Infrared Spectroscopy of DC3N in the Stretching Region
Frontiers in Astronomy and Space Sciences, 2021 The perspectives opened by modern ground-based infrared facilities and the forthcoming James Webb Telescope mission have brought a great attention to the ro-vibrational spectra of simple interstellar molecules.
Ningjing Jiang +9 more
doaj +1 more source
Hyperfine interaction in cobalt by high-resolution neutron spectroscopy
, 2018 We have investigated the ferromagnetic phase transition of elemental Co by high-resolution neutron backscattering spectroscopy. We monitored the splitting of the nuclear levels by the hyperfine field at the Co nucleus.
Chatterji, Tapan +2 more
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
An Earth-sized Planet around an M5 Dwarf Star at 22 pc
The Astronomical Journal, 2023 We report on the discovery of an Earth-sized transiting planet ( R _p = 1.015 ± 0.051 R _⊕ ) in a P = 4.02 day orbit around K2-415 (EPIC 211414619), an M5V star at 22 pc.
Teruyuki Hirano +48 more
doaj +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
High resolution X-ray spectroscopy and imaging of Mrk573
, 2010 We present a detailed analysis of the XMM-Newton RGS high resolution X-ray spectra of the Seyfert 2 galaxy, Mrk573. This analysis is complemented by the study of the Chandra image, and its comparison to optical (HST) and radio (VLA) data.
Anders +61 more
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Calibrating the Instrumental Drift in MAROON-X Using an Ensemble Analysis
The Astronomical JournalMAROON-X is a state-of-the-art extreme-precision radial velocity spectrograph deployed on the 8.1 m Gemini-N telescope on Maunakea, Hawai’i. Using a stabilized Fabry–Pérot etalon for wavelength and drift calibration, MAROON-X has achieved a short-term ...
Ritvik Basant +9 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source