Results 71 to 80 of about 4,939,655 (307)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Study on the Influence of a Powered Nacelle on the Wake Vortex Characteristics of Wide-Body Aircraft

Aerospace
The aircraft wake vortex is an important factor affecting flight safety; as an important part of the aircraft, the powered nacelle will inevitably have an important impact on the aircraft wake vortex, so it is of great practical significance to research ...
Hexiang Wang, Junqiang Wu, Qiuting Guo, Guangyuan Liu, Jifei Wu, Dawei Liu, Yang Tao, Neng Xiong   +7 more
doaj   +1 more source

High speed multi focal plane optical system [PDF]

, 1983
An apparatus for eliminating beamsplitter generated optical aberrations in a pupil concentric optical system providing a plurality of spatially separated images on different focal planes or surfaces is presented.
Minott, P. O.
core   +1 more source

Distributed associative memories for high-speed symbolic reasoning [PDF]

, 1996
This paper briefly introduces a novel symbolic reasoning system based upon distributed associative memories which are constructed from correlation matrix memories (CMM). The system is aimed at high-speed rule-based symbolic operations.
Austin, J
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Influence of Double-Ducted Serpentine Nozzle Configurations on the Interaction Characteristics between the External and Nozzle Flow of Aircraft

Aerospace
To clarify the influence of the serpentine nozzle configurations on the flow characteristics and aerodynamic performance of aircraft, the flow features and aerodynamic performances of the double-ducted serpentine nozzles with different aspect ratios (AR),
Jilong Zhu, Yi Zhang, Yaohua Li, Liquan Zeng, Lei Miao, Neng Xiong, Yang Tao   +6 more
doaj   +1 more source

Data processing and uncertainty evaluation method for five-hole probe considering compressibility [PDF]

AIP Advances
The data processing and uncertainty evaluation method of the five-hole probe, considering compressibility, is studied to meet the application requirements of the five-hole probe in a high-speed wind tunnel.
Yufeng Du, Lulu Wang, Qiuting Guo, Jilong Zhu, Neng Xiong   +4 more
doaj   +1 more source

Electro-optic polymers for high speed modulators [PDF]

, 2005
Different electro-optic polymer systems are analyzed with respect to their electro-optic activity, glass transition temperature (Tg) and photodefinable properties. The polymers tested are polysulfone (PS) and polycarbonate (PC).
Balakrishnan, M, Diemeer, M.B.J., Driessen, A., Faccini, M., Leinse, A., Reinhoudt, D.N., Verboom, W.   +6 more
core   +1 more source

Deep Learning for High Speed Optical Coherence Elastography

, 2020
Mechanical properties of tissue provide valuable information for identifying lesions. One approach to obtain quantitative estimates of elastic properties is shear wave elastography with optical coherence elastography (OCE).
Bengs, Marcel, Latus, Sarah, Neidhardt, Maximilian, Saathoff, Thore, Schlaefer, Alexander, Schlüter, Matthias   +5 more
core   +1 more source