Results 81 to 90 of about 1,223,767 (265)

Concurrent Treatment With Lorlatinib and Dinutuximab Beta Induced Acute Gastric Dilation in a Pediatric Patient With Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
Suna Lin, Linjie Li, JiJun Chen, Zhaokun Tao, Lifeng Zhang, Junqing Mao, Jinhu Wang   +6 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation of balance measurement uncertainty based on standard error of calibration coefficients

Kongqi donglixue xuebao
The measurement uncertainty of strain gauge balance is one of the important sources of uncertainty in aircraft wind tunnel test data. The conventional methodology obtains the balance calibration formula through the comprehensive loading residual method ...
Chao Wang, Bin Xie, Qiang Li, Renhui Tian, Weiqiang Zhao   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Experimental study on the mechanical properties of fly ash stabilized bentonite via sodium hydroxide-geopolymerization process

Scientific Reports
Expansive clay is problematic for transportation infrastructures due to its vulnerability to water induced decrease in strength. Building on existing geopolymer stabilization techniques, this study focuses on optimizing the mix design for expansive soils
Tengshen Jing, Shengyang Yuan, Xianfeng Liu, Yulin Liu, Haibin Xu, Weixing Zhou, Gaofeng Pan, Guanlu Jiang   +7 more
doaj   +1 more source

Data-driven capacity planning of highway multi-energy systems under photovoltaic uncertainty using CVAE-enhanced distributionally robust optimization

Frontiers in Energy Research
Capacity planning in highway multi-energy systems faces significant challenges due to the high uncertainty of renewable energy generation and the limited availability of historical data during the planning stage.
Guomu Xie, Guomu Xie, Xuefei Liu, Hongjie Li, Hongjie Li, Yuanyuan Song, Jikai Fu, Jikai Fu, Jibin Zhang, Jibin Zhang, Shishan Dong, Shishan Dong   +11 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Simulation on Buffet Response and Mitigation of Variant-Tailed Aircraft in Maneuver State

Vibration
This study proposes a computational fluid dynamics and computational structure dynamics (CFD/CSD) coupled method for calculating the buffet response of a variant tail wing.
Dawei Liu, Peng Zhang, Binbin Lv, Hongtao Guo, Li Yu, Yanru Chen, Bo Lu   +6 more
doaj   +1 more source