Results 121 to 130 of about 1,842,676 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A magnetically isolated gate driver for high-speed voltage sharing in series-connected MOSFETs [PDF]

, 2011
A scalable resonant gate drive circuit is described, suitable for driving series-connected MOSFETs in high-voltage, high-speed inverter applications for resistive and capacitive loads.
Anthony, Philip, Grant, Duncan, Hearn, George, Holliday, Derrick, McNeill, Neville   +4 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Modeling and Simulation on the Hybrid Solution of Static Var Generator and Synchronous Condenser for Unlocking Power Output Limitation of Wind Farms Integrated into Weak Grid

Energies
The issues of low inertia, overvoltage, and wide-frequency oscillations in high-proportion renewable energy systems have become prominent, posing major challenges to renewable energy integration and threatening grid stability.
Haiyang Liang, Yanbin Zhang, Shuran Liu, Jianling Wu, Jifeng Fan, Yi Zhang, Junjie Yu, Tianlong Zhang, Ziyi Zhu   +8 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Graphene aerogel for supercapacitors: influence of hydrothermal reduction parameters on electrochemical performance

Scientific Reports
In the present work, a hydrothermal reduction method is used to further enhance and optimize the pristine graphene aerogels (GAs) for supercapacitors.
Khaled Abdou Ahmed Abdou Elsehsah, Zulkarnain Ahmad Noorden, Norhafezaidi Mat Saman, Noor Azlinda Ahmad, Mohd Faizal Hasan   +4 more
doaj   +1 more source

Design and Implementation of Security Audit and Monitoring System in Network Security Risk Perception of Power Monitoring System

Journal of Applied Science and Engineering
This study tackles challenges in server O&M and network security by proposing an ALBERTbased knowledge graph framework. Traditional methods face low information correlation, incomplete entity extraction, and inefficient decision-making.
Ruizhi Zhang, Hong Jia, Boyan Song, Changjin Xu, Xiaolin Zhang   +4 more
doaj   +1 more source

Design and Vertical Tests of SPS-series Double-Quarter Wave (DQW) Cavity Prototypes for the HL-LHC Crab Cavity System

, 2018
Crab crossing is essential for high-luminosity colliders. The High Luminosity Large Hadron Collider (HL-LHC) will equip one of its Interaction Points (IP1) with Double-Quarter Wave (DQW) crab cavities.
Artoos, K., Belomestnykh, S., Ben-Zvi, I., Boulware, C., Burt, G., Calaga, R., Capatina, O., Carra, F., Castilla, A., Clemens, W., Grimm, T., Kuder, N., Leuxe, R., Li, Z., McEwen, E. A., Park, H., Powers, T., Ratti, A., Shipman, N., Skaritka, J., Verdú-Andrés, S., Wu, Q., Xiao, B. P., Yancey, J., Zanoni, C.   +24 more
core   +1 more source