Results 91 to 100 of about 146,755 (292)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The application of classical conditioning to the machine learning of a commonsense knowledge of visual events [PDF]

, 2013
In the field of artificial intelligence, possession of commonsense knowledge has long been considered to be a requirementto construct a machine that possesses artificial general intelligence.
Furze, Timothy Andrew
core  

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ, Holt, Beatrice, Holt, B., Kalisch, R, Büchel, C, Martino, Benedetto de, Büchel, Christian, Dolan, R. ; https://orcid.org/, Kalisch, R., Büchel, C., Holt, B, Klöppel, Stefan, Dolan, R.J., Petrovic, P,, Petrovic, P., Petrovic, Predrag, De Martino, B., Klöppel, S., Dolan, Raymond J., De, Martino B, Kalisch, Raffael, Klöppel, S   +21 more
core   +2 more sources

Research on Matching Optimal State Points of Air Conditioning Performance

Zhileng xuebao, 2020
In order to match the best state point of air-conditioning performance, this paper selects an air conditioning unit with a refrigerating capacity of 5.15 kW as a research object.
Yu Zhen, Chen Haining, Pan Likui, Wang Fuqiang   +3 more
doaj  

Hierarchical Optimization of Landing Performance for Lander with Adaptive Landing Gear

Chinese Journal of Mechanical Engineering, 2019
A parameterized dynamics analysis model of legged lander with adaptive landing gear was established. Based on the analysis model, the landing performances under various landing conditions were analyzed by the optimized Latin hypercube experimental design
Zongmao Ding, Hongyu Wu, Chunjie Wang, Jianzhong Ding   +3 more
doaj   +1 more source

A Review of Backward Higher-Order Conditioning: Implications for a Pavlovian Conditioning Analysis of Stimulus Equivalence. [PDF]

Perspect Behav Sci, 2023
Alonso-Alvarez B.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Globalization, Chinese-Culture and the Expansion of Higher Education System in Taiwan

International Journal of Chinese Education, 2013
The global market gives nation-states no choice but to be subject to its rules. As a result, they need to modify themselves to meet its requirements in order to gain access to the considerable amount of capitalist profit available.
Tien-Hui Chiang
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Behavioural and Neural Analyses of Higher-Order Fear Conditioning [PDF]

Memories about aversive events that elicit fear can imbue fear to other stimuli. This is studied using Pavlovian higher-order fear conditioning. A stimulus that is directly paired with an aversive outcome (i.e., Pavlovian first-order fear conditioning ...
Gostolupce, Dilara Esin
core