Results 81 to 90 of about 146,755 (292)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Cooling NZ: institutional drivers behind the growth in air-conditioning [PDF]
, 2012 Cooling by air-conditioning in buildings has been claimed to be addictive to the occupants. But for every addict there is ‘pusher’ who has introduced and supplies the product.
Hemyza Budin (17932853) +1 more
core +2 more sources
Chengshi guidao jiaotong yanjiu[Objective] When tunnel boring machine advancing in the water-rich sand layer, problems such as high cutter torque, serious wear and spout of the screw conveyer can be easily generated.
Xuanrong ZHENG +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The influence of classical-conditioning procedures on subsequent attention to the conditioned brand. [PDF]
Three experiments are used to investigate the influence of conditioning procedures on attention to a conditioned stimulus. In experiment 1, scenes presented in a sequence that is consistent with prescribed conditioning procedures are shown to encourage ...
Janiszewski, C, Warlop, Luk
core
Finite-difference solutions of tenth-order boundary-value problems [PDF]
, 1994 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In this thesis finite difference methods are used to obtain numerical solutions for a class of high-order ordinary differential equations with applications ...
Siddiqui, Aijaz Ahmad
core
Sex Differences in Remote Contextual Fear Generalization in Mice
Frontiers in Behavioral Neuroscience, 2019 The generalization of fear is adaptive in that it allows an animal to respond appropriately to novel threats that are not identical to previous experiences.
Arun Asok +13 more
doaj +1 more source