Results 81 to 90 of about 109,071 (235)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Higher Order Conditions in Nonlinear Optimal Control

, 2011
The most widely used tool for the solution of optimal control problems is the Pontryagin Maximum Principle. But the Maximum Principle is, in general, only a necessary condition for optimality. It is therefore desirable to have supplementary conditions, for example second order sufficient conditions, which confirm optimality (at least locally) of an ...
Gavriel, Christos, Gavriel, Christos
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Experimental Study on Compressor-driven Loop Heat Pipe for Data Center Cooling

Zhileng xuebao, 2020
In order to get better performance of power-assisted heat pipe systems, the performance of three types of compressors was experimentally studied. The results show that: 1) a compressor with gas pump function has the function of a low compression ratio ...
Wang Fei, Shao Shuangquan, Zhang Hainan
doaj  

Higher-order homogenised riblet boundary conditions

The description of riblets and other drag-reducing devices has long used the concept of longitudinal and transverse protrusion heights, both as a means to predict the drag reduction itself and as equivalent boundary conditions to simplify numerical simulations by transferring the effect of riblets onto a flat virtual boundary.
Luchini, Paolo, Chung, Daniel
openaire   +2 more sources

Higher-Order Far-Field Boundary Conditions for Crystalline Defects

SIAM Journal on Numerical Analysis
Crystalline materials exhibit long-range elastic fields due to the presence of defects, leading to significant domain size effects in atomistic simulations. A rigorous far-field expansion of these long-range fields identifies low-rank structure in the form of a sum of discrete multipole terms and continuum correctors.
Julian Braun, Christoph Ortner, Yangshuai Wang, Lei Zhang   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Appetitive and aversive visual learning in freely moving Drosophila

Frontiers in Behavioral Neuroscience, 2010
To compare appetitive and aversive visual memories of the fruit fly Drosophila melanogaster, we developed a new paradigm for classical conditioning. Adult flies are trained en masse to differentially associate one of two visual conditioned stimuli (blue ...
Christopher Schnaitmann, Christopher Schnaitmann, Katrin Vogt, Katrin Vogt, Tilman Triphan, Hiromu Tanimoto, Hiromu Tanimoto   +6 more
doaj   +1 more source

Statefinders, higher-order energy conditions, and sudden future singularities [PDF]

Physics Letters B, 2005
We link observational parameters such as the deceleration parameter, the jerk, the kerk (snap) and higher-order derivatives of the scale factor, called statefinders, to the conditions which allow to develop sudden future singularities of pressure with finite energy density.
openaire   +2 more sources