Results 131 to 140 of about 4,290,191 (312)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Dataset for 'A Paper-based Loop-Mediated Isothermal Amplification Assay for Highly Pathogenic Avian Influenza'

This dataset contains raw data used during the creation of an assay for detection of highly-pathogenic avian influenza (HPAI) virus type H5 (H5) and used for the publication in the article 'A Paper-based Loop-Mediated Isothermal Amplification Assay for ...
Davidson, Josiah Levi
core   +1 more source

A Systematic Approach on Highly Potent Pathogens [PDF]

Journal of Bioprocessing & Biotechniques, 2014
The need for the contained handling and processing of pharmaceutical materials and pathogens is on the rise due to the increased focus on health and safety and the growing interest in the development of High Potency Active Pharmaceutical Ingredients (HPAPIs).
openaire   +1 more source

Rapid spread of MPXV clade Ib with high genetic relatedness among men who have sex with men, Berlin, Germany, week 50 2025 up to week 10 2026

Eurosurveillance
Following the first detection of monkeypox virus (MPXV) clade Ib in Berlin, Germany, in December 2025, clade Ib rapidly predominated over clade IIb among notified mpox cases.
Janine Michel
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Three-monthly rolling average of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh in 2007–2011.

, 2014
Three-monthly rolling average of highly pathogenic avian influenza (H5N1) outbreaks in Bangladesh in 2007–2011.
Mat Yamage (571119), Md. Zohorul Islam (545573), Nitish C. Debnath (571118), Paritosh K. Biswas (176298)   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The efficacy of current vaccines and novel Nanobody-based antivirals against highly pathogenic rabies and lyssaviruses

, 2010
Current rabies virus (RABV; lyssavirus genotype 1) vaccines and RABV immunoglobulins (RIG) confer a robust protective immunity against genotype 1 isolates.
van Gucht, S., Vaughan, A., de Haard, H.J., Hultberg, A., Koenders, M., Fooks, A.R., Verrips, T., Wright, E., Saunders, M., Rosseels, V., Weiss, R.A., Vanlandschoot, P.   +11 more
core  

Predicted probability to encounter highly pathogenic strains (i.e. induced mortality >25%) for each sampling month.

, 2014
Predicted probability to encounter highly pathogenic strains (i.e. induced mortality >25%) for each sampling month.
Carolin C. Wendling (551031), Frederico M. Batista (551032), K. Mathias Wegner (51516)   +2 more
core   +1 more source