DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
The vertical axis represents the monthly incidence of highly pathogenic influenza cases based on the provincial surveillance data. X-axis shows the corresponding time of each monthly surveillance data of highly pathogenic influenza.
Bin Peng (31749) +3 more
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades [PDF]
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1,2. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 3.
Hala M. Esmat +10 more
core
Biological and control measure model parameters used for highly pathogenic H5N1 in Nigeria.
Biological and control measure model parameters used for highly pathogenic H5N1 in Nigeria.
Ariel Rivas (735587) +11 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Highly pathogenic avian influenza reported in Russian bird populations
The highly pathogenic avian influenza virus type A(H5N1), which continues to infect humans in Vietnam and Indonesia, has been reported to have infected bird populations in ...
Collective Editorial team
core +1 more source
Highly pathogenic avian influenza and wild birdsr
Highly pathogenic avian influenza virus (HPAIV) subtype H5N1 prevails worldwide and causes serious problems in poultry industry. The virus is also known as one of the most important zoonotic agents derived from avian species. Because many bird species other than poultry such as chicken and duck are susceptible for HPAIV infection, wild birds are ...
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source

