Results 101 to 110 of about 852,985 (355)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Urine metabolomic analyses reveal metabolite disruptions in steroid hormone biosynthesis in monkeypox

iScience
Summary: Monkeypox virus (MPXV) poses a global health threat. Viral infection can alter host metabolic homeostasis, while its changes may influence disease severity and progression. The relationship between MPXV and metabolites has not been reported.
Xiaofeng Yang, Huiqin Yang, Chudan Liang, Fei Tang, Zhenyu Long, Linjin Fan, Yulong Wang, Zequn Wang, Mou Zeng, Weifang Kang, Pengfei Ye, Wendi Shi, Yuandong Zhou, Jingyan Lin, Hongxin Huang, Huijun Yan, Jian Wang, Linghua Li, Jun Qian, Linna Liu   +19 more
doaj   +1 more source

De novo variants disturbing the transactivation capacity of POU3F3 cause a characteristic neurodevelopmental disorder

, 2019
POU3F3, also referred to as Brain-1, is a well-known transcription factor involved in the development of the central nervous system, but it has not previously been associated with a neurodevelopmental disorder.
Au, C., Baker, S., Bergstrom, K., Bodek, S., Brunner, H., Cunniff, C., Dentici, M., Derizioti, P., Faivre, L., Firth, H., Fisher, S., Gilissen, C., Iglesias, A., Izumi, K., Kleefstra, T., Kroes, H., Lachmeijer, A., Leonard, J., Maas, S., Matsumoto, N., Miyake, N., Niceta, M., Okamoto, N., Pfundt, R., Philippe, C., Powis, Z., Shinde, D., Snijders Blok, L., Tang, S., Tartaglia, M., Tayoun, A., Tomkins, S., Van Gassen, K., Venselaar, H., Vitobello, A., Wiel, L., Wojcik, M., Õunap, K.   +37 more
core   +1 more source

Drivers of disease emergence and spread: Is wildlife to blame? [PDF]

, 2014
The global focus on wildlife as a major contributor to emerging pathogens and infectious diseases (EIDs) in humans and domestic animals is not based on field, experimental or dedicated research, but mostly on limited surveys of literature, opinion and ...
Kock, R A
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Knowledge discovery from mining the association between H5N1 outbreaks and environmental factors [PDF]

, 2010
The global spread of highly pathogenic avian influenza H5N1 in poultry, wild birds and humans, poses a significant panzootic threat and a serious public health risk.
Prins, H.H.T., Si, Y., Skidmore, A.K., Wang, T.   +3 more
core   +6 more sources

How Highly Pathogenic Avian Influenza (H5N1) Has Affected World Poultry-Meat Trade [PDF]

In 2003, outbreaks of the highly pathogenic avian influenza (HPAI) H5N1 virus had a major negative impact on the global poultry industry. Initially, import demand for both uncooked and cooked poultry declined substantially, due to consumers’ fear of ...
Taha, Fawzi A.
core   +1 more source

Wild birds in south china agro-ecosystems and long-distance spread of H5N1 [PDF]

, 2011
Agricultural intensification in South China has increased densities of domestic ducks raised on intensively irrigated paddy fields, an important factor in the persistence of H5N1 highly pathogenic avian influenza virus (HPAIV).
Cappelle, Julien, Newman, Scott, Takekawa, John Y., Xiao, Xiangming, Zhao, Delong   +4 more
core  

Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]

, 2020
Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita, Barbaro, Brett A., Bornemann, Douglas J., Burke, John, Chin, Theodore M., Chongtham, Anjalika, Lukacsovich, Tamas, Marsh, J. Lawrence, Purcell, Judith, Syed, Adeela, Worthge, Shane   +10 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source