Results 71 to 80 of about 4,290,191 (312)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Animal models for highly pathogenic emerging viruses

Current Opinion in Virology, 2013
Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East.
Safronetz, David, Geisbert, Thomas W, Feldmann, Heinz   +2 more
openaire   +2 more sources

Flexible upscaling of laboratory PCR testing capacity at the Robert Koch Institute during the SARS-CoV-2 pandemic

Virology Journal, 2023
Background Over the course of the COVID-19 pandemic, laboratories worldwide have been facing an unprecedented increase in demand for PCR testing because of the high importance of diagnostics for prevention and control of virus spread.
Eva Krause, Janine Michel, Andreas Puyskens, Natalie Hofmann, Thomas Rinner, Barbara Biere, Brigitte G. Dorner, Martin Skiba, Lars Schaade, Andreas Nitsche   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

H5N1 Clade 2.2 Polymorphism Tracing Identifies Influenza Recombination and Potential Vaccine Targets [PDF]

, 2007
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 2.
Nasr M. ElSayed, A Nayei, A A. Abdelghani, Jeffery Tjaden, Mona Aly, Marshall Monteville, Hala Essmat, A Abdelghani, Bruce Boynton, A I. Nayei, Henry Niman, Moustafa Mansour, Kenneth Earhart, Henry L. Niman, Magdi Saad, Moustafa M. Mansour, Hala M. Essmat, Mona M. Aly, Nasr ElSayed, Magdi D. Saad, A-SA Arafa, Kenneth C. Earhart, Elassai Labib, Bruce R. Boynton, E Ayoub, Marshall R. Monteville, Elassai M. Labib   +26 more
core   +1 more source

Parallel evolution in the emergence of highly pathogenic avian influenza a viruses [PDF]

, 2020
: Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses (AIV).
Keown, J R, Keown, Jeremy R., Escalera-Zamudio, M, Bowden, T A, Carrique, L, Pybus, Oliver G., Bowden, Thomas A., Gutiérrez, Bernardo, Carrique, Loic, Golden, M, Thézé, J, Golden, Michael, Pybus, O G, Escalera-Zamudio, Marina, Bowden, Thomas, A, Pybus, Oliver, G, Bowden, Thomas,, Julien Thézé, Loic Carrique, Thomas A. Bowden, Bernardo Gutiérrez, Pybus, Oliver,, Marina Escalera-Zamudio, Keown, Jeremy Russell, Oliver G. Pybus, Jeremy Russell Keown, Michael Golden, Gutiérrez, B, Thézé, Julien   +28 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modelling control of avian influenza in poultry: the link with data [PDF]

, 2009
In this paper the authors discuss the use of modelling in the evaluation of strategies designed to control epidemics of highly pathogenic avian influenza (HPAI) in poultry.
Jong, M.C.M., de, Hagenaars, T.H.J.
core