Results 171 to 180 of about 78,402 (305)

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

Objective lameness assessment of 235 horses undergoing lameness examination in Brazil: A retrospective study. [PDF]

Braz J Vet Med
Rodrigues APDC, Pozzobon R, De Bastiani G, De La Côrte FD, Azevedo MDS.   +4 more
europepmc   +1 more source

Comparative Myology and Evolution of Marsupials and Other Vertebrates, With Notes on Complexity, Bauplan, and "Scala Naturae" [PDF]

, 2016
Appleton AB., Bonner JT., Brooks HSJ., Brooks HSJ., Coues E., Coues E., Diogo R, Diogo R., Eble GJ., Eble GJ., Edgeworth FH., Gregory WK, Haines RW., Hiiemae K, Huber E., Jouffroy FK, Jouffroy FK, Jouffroy FK., Kardong KV., Lander KF., Lewis OJ., Lightoller GS., Lightoller GS., Lightoller GS., Osgood WH., Pearson JS., Saban R., Schaeffer JP., Sears KE., Straus WL., Straus WL., Symington J., Thompson P, Young AH.   +33 more
core   +2 more sources

New perspectives on body size and shape evolution in dinosaurs

Biological Reviews, EarlyView.
ABSTRACT Diversity in the body shapes and sizes of dinosaurs was foundational to their widespread success during the Mesozoic era. The ability to quantify body size and form reliably is therefore critical to the study of dinosaur biology and evolution.
Matthew Dempsey, Samuel R. R. Cross, Susannah C. R. Maidment, John R. Hutchinson, Karl T. Bates   +4 more
wiley   +1 more source

A Retrospective Study of the Evolution of Orthopaedic Injuries in 70 Dressage Horses. [PDF]

Animals (Basel)
Boado A, Pollard D, Dyson S.
europepmc   +1 more source

Generation and Auditory Phenotypic Characterization of Prps1 p.Ala87Thr Mouse Knock‐In Model for Human DFNX1 Deafness

Clinical Genetics, EarlyView.
Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan, M'hamed Grati, Rahul Mittal, Yi‐Zhou Quan, Wan Du, Zheng‐Yi Chen, Xue Zhong Liu   +6 more
wiley   +1 more source

Acute administration of lovastatin had no pronounced effect on motor abilities, motor coordination, gait nor simple cognition in a mouse model of Angelman syndrome. [PDF]

J Neurodev Disord
Fenton TA, Petkova SP, Adhikari A, Silverman JL.   +3 more
europepmc   +1 more source

Further Exploring the TRRAP Genotype–Phenotype Correlations: Report of Three New Patients With A Focus on Skeletal Anomalies

Clinical Genetics, EarlyView.
We report on the clinical characteristics of three new patients with pathogenic TRRAP variants expanding the syndrome's phenotype. In order to investigate the TRRAP potential involvement in skeletal development, osteoclastogenesis in Patient 1 was evaluated and TRRAP expression in osteoclasts and osteoblasts were analyzed.
Chiara Minotti, Sara Terreri, Andrea Del Fattore, Francesca Romana Lepri, Rosario Ruta, Maria Iascone, Laura Pezzoli, Maria Lisa Dentici, Antonio Novelli, Michelina Armando, Daniela Longo, Giuseppe Novelli, Domenico Barbuti, Andrea Bartuli, Ugo Cavallari, Ludovico Graziani, Maria Cristina Digilio, Lorenzo Sinibaldi   +17 more
wiley   +1 more source

IDO1 improves postischemic neovascularization in aged mice by boosting endothelial NAD⁺ de novo synthesis and curbing endothelial senescence. [PDF]

Redox Biol
Chen M, Chen J, Liu Y, Chen J, Yao M, Wang X, Zhang J, Pan M, Zhou J, Bai Y.   +9 more
europepmc   +1 more source

TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization‐Mediated Autophagy

Cell Proliferation, EarlyView.
TREM2 exacerbates spinal cord injury by inhibiting TFEB nuclear translocation, aggravating lysosomal membrane permeabilisation and consequently suppressing autophagy. ABSTRACT Microglia, considered as the main immune responder, play an important role in regulating neuroinflammation in central nervous system (CNS) disorders. Our previous work found that
Tianlun Zhao, Jiawei Di, Yu Kang, Haojie Zhang, Senyu Yao, Bin Liu, Limin Rong   +6 more
wiley   +1 more source