Results 11 to 20 of about 46,422 (268)
Hippo Signaling in the Endometrium
International Journal of Molecular Sciences, 2022 The uterus is essential for embryo implantation and fetal development. During the estrous cycle, the uterine endometrium undergoes dramatic remodeling to prepare for pregnancy. Angiogenesis is an essential biological process in endometrial remodeling. Steroid hormones regulate the series of events that occur during such remodeling.
Sohyeon Moon +8 more
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Cold Spring Harbor Perspectives in Biology, 2012 The Hippo pathway regulates tissue growth, and inactivation of any of four key components (HPO, WTS, SAV, and MATS) results in tissue overgrowth. Cell junctions may also modulate the pathway's activity.
Kieran F, Harvey, Iswar K, Hariharan
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Genes & Development, 2011 The Hippo pathway coordinates organ size and cell proliferation. The retinoblastoma family of proteins regulates progression through the G0/G1 phase of the cell cycle. Disruption of either pathway contributes to cancer formation. Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways ...
Dick, Frederick A., Mymryk, Joe S.
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Developmental Cell, 2017 Normal organ growth requires precise signaling from key developmental pathways, as well as careful coordination between these pathways. In this issue of Developmental Cell, Pascual and colleagues (2017) investigate the dire consequences of simultaneous deregulation of both the Ras and Hippo pathways.
Taryn M, Sumabat, Iswar K, Hariharan
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Cell Death & Differentiation, 2017 The three p53 family members, p53, p63 and p73, are structurally similar and share many biochemical activities. Yet, along with their common fundamental role in protecting genomic fidelity, each has acquired distinct functions related to diverse cell autonomous and non-autonomous processes. Similar to the p53 family, the Hippo signaling pathway impacts
Noa, Furth, Yael, Aylon, Moshe, Oren
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Hippo signaling at a glance [PDF]
Journal of Cell Science, 2010 How the organs of multicellular organisms develop to a pre-defined size is a fundamental question in biology, but little is known about the underlying mechanisms. In the past decade, the Hippo pathway has been revealed to play a crucial role in organ size control (reviewed by [Zhao et al., 2010a ...
Bin, Zhao, Li, Li, Kun-Liang, Guan
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Hippo Enters the Competition [PDF]
Developmental Cell, 2019 In this issue of Developmental Cell, Hashimoto and Sasaki (2019) explore the role of the Hippo pathway in the establishment of naive pluripotency and cell competition in the epiblast. Their work gives insight into how the mouse embryo selects cells with the highest future potential, through the activity of YAP/TEAD.
Christophe, Royer, Shankar, Srinivas
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The EMBO Journal, 2011 The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal , Sansores‐Garcia et al (2011) report that modulation of filamentous (F)‐actin accumulation controls Hpo pathway activity. In a related study, Garcia‐Fernandez et al
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Mechanoregulation and pathology of YAP/TAZ via Hippo and non‐Hippo mechanisms [PDF]
Clinical and Translational Medicine, 2018 AbstractYes‐associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. On the tissue level, YAP/TAZ are essential for embryonic development, organ size control and regeneration, while their deregulation leads ...
Oleg Dobrokhotov +3 more
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Frontiers in Oncology, 2023 IntroductionHepatocellular carcinoma (HCC) prevalence is rising annually, but the existing treatment strategies are limited; therefore, it is crucial to explore new therapeutic approaches.MethodsHere, we investigate the potential anti-cancer mechanism of
Mingyuan Tao +3 more
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