Cell Death & Differentiation, 2017 The three p53 family members, p53, p63 and p73, are structurally similar and share many biochemical activities. Yet, along with their common fundamental role in protecting genomic fidelity, each has acquired distinct functions related to diverse cell autonomous and non-autonomous processes. Similar to the p53 family, the Hippo signaling pathway impacts
Noa, Furth, Yael, Aylon, Moshe, Oren
openaire +2 more sources
The Hippo Pathway and Viral Infections
Frontiers in Microbiology, 2020 The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang +5 more
doaj +1 more source
Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis
eLife, 2023 Idiopathic pulmonary fibrosis (IPF) consists of fibrotic alveolar remodeling and progressive loss of pulmonary function. Genetic and experimental evidence indicates that chronic alveolar injury and failure to properly repair the respiratory epithelium ...
Rachel Warren +3 more
doaj +1 more source
Role of yes-associated protein in resistance of HER2+ breast cancer to lapatinib
Di-san junyi daxue xuebao, 2020 Objective To construct a lapatinib-resistant breast cancer cell line, and to study the role and underlying mechanism of yes-associated protein (YAP) in Hippo signaling pathway in the process.
CHEN Peng, XU Ting, GUO Dan, HUANG Jiayi
doaj +1 more source
SARS-CoV-2 Infection in Captive Hippos (Hippopotamus amphibius), Belgium
Animals, 2023 Two adult female hippos in Zoo Antwerp who were naturally infected with SARS-CoV-2 showed nasal discharge for a few days. Virus was detected by immunocytochemistry and PCR in nasal swab samples and by PCR in faeces and pool water.
Francis Vercammen +14 more
doaj +1 more source
Towards understanding the variability in biospheric CO2 fluxes:Using FTIR spectrometry and a chemical transport model to investigate the sources and sinks of carbonyl sulfide and its link to CO2 [PDF]
, 2016 Understanding carbon dioxide (CO2) biospheric processes is of great importance because the terrestrial exchange drives the seasonal and interannual variability of CO2 in the atmosphere. Atmospheric inversions based on CO2 concentration measurements alone
A. Wolf +18 more
core +4 more sources
Mechanisms of YAP/TAZ transcriptional control
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor ...
Giusy Battilana +2 more
doaj +1 more source
The Role of RASSF5 on Cell Growth and Hippo Signaling in Rhabdomyosarcoma [PDF]
, 2020 Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. Dysregulation of the Hippo pathway, a signaling cascade that regulates many biological processes, is associated with many human cancers.
Garver, Megan +2 more
core +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Resource partitioning among African savanna herbivores in North Cameroon: the importance of diet composition, food quality and body mass [PDF]
, 2011 The relationship between herbivore diet quality, and diet composition (the range of food plants consumed) and body mass on resource partitioning of herbivores remains the subject of an ongoing scientific debate.
Brunsting, A.M.H. +6 more
core +2 more sources