Results 41 to 50 of about 114,310 (305)

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell [PDF]

, 2012
During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which
A. Hoffmann, Bachmann, Bachmann, Bachmann, Bannard, Camargo, Chai, Choi, Cretney, D. T. Fearon, Dong, Feau, Gong, H. Lingel, Harrington, Hegel, J. E. D. Thaventhiran, Kalia, Kallies, Katagiri, Khanna, Kwon, L. Magiera, Lee, M. Brunner-Weinzierl, M. de la Roche, Nishioka, Pearce, Pipkin, Rao, Russ, Rutishauser, Sabatos, Schlegelmilch, Sun, Taylor, Turner, Voehringer, Waterhouse, Williams, Yeo, Zhao, Zhou   +42 more
core   +1 more source

Tata Kelola Demokrasi: Membangkitkan Semangat Pengawasan, Pengetahuan, Kesadaran, dan Partisipasi Politik Mahasiswa Melalui Program Sosialisasi

Jurnal Kewarganegaraan
The research method used in this research is associative quantitative research. The population of this study were all students of San Agustin Hippo Catholic University who participated in the election monitoring socialization program in 2023, totaling ...
Apolonius Yonas, Oxtapianus Tawarik, Sapomo Sapomo, Pebrianus Hendri   +3 more
doaj   +1 more source

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

Cells, 2020
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces.
Mathias Cobbaut, Simge Karagil, Lucrezia Bruno, Maria Del Carmen Diaz de la Loza, Francesca E Mackenzie, Michael Stolinski, Ahmed Elbediwy   +6 more
doaj   +1 more source

Hepatic Hippo signaling inhibits development of hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology, 2020
Primary liver cancer is one of the most common cancer worldwide. Hepatocellular carcinoma (HCC) in particular, is the second leading cause of cancer deaths in the world.
Yuchen Liu, Xiaohui Wang, Yingzi Yang
doaj   +1 more source

Evaluating the role of the Hippo pathway in the onset and disease progression of the SOD1 mouse model of amyotrophic lateral sclerosis [PDF]

, 2016
The Hippo pathway is a cell signaling pathway involved in organ size regulation and tumorigenesis in mammals. This pathway regulates the activity of Yes-associated protein (YAP), a transcriptional coactivator which binds to the transcription factor TEAD ...
Granucci, Eric
core   +1 more source

Glucocorticoid receptor signalling activates YAP in breast cancer [PDF]

, 2017
The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo pathway leads to aberrant activation of the transcription co-activator YAP ...
Bertolio, Rebecca, Bicciato, Silvio, Cappuzzello, Elisa, Del Sal, Giannino, Forcato, Mattia, Ingallina, Eleonora, Mano, Miguel, Marotta, Carolina, Neri, Carmelo, Rosato, Antonio, Ruggeri, Naomi, Sorrentino, Giovanni, Zannini, Alessandro   +12 more
core   +3 more sources

How Toll Met Hippo [PDF]

Developmental Cell, 2016
Toll and Hippo are two seemingly disparate pathways that regulate innate immunity and tissue growth, respectively. Reporting recently in Cell, Liu et al. (2016) tie them together by demonstrating that microbial infection activates Toll, which then signals to both pathways to modulate the antimicrobial response.
Nie, Yingchao, Ip, Y. Tony
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti, Greene, Mark I, Morvaridi, Susan, Pandol, Stephen J, Wang, Qiang   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source