Results 61 to 70 of about 114,310 (305)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Chest wall restriction device for modeling respiratory challenges and dysfunction

Frontiers in Medical Engineering
Breathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues, Lizuannette Mejia, Rafael G. Zucchi, Paul W. Davenport, Nicholas J. Napoli   +4 more
doaj   +1 more source

The Role of Mst1 in Lymphocyte Homeostasis and Function

Frontiers in Immunology, 2018
The Hippo pathway is an evolutionarily conserved pathway crucial for regulating tissue size and for limiting cancer development. However, recent work has also uncovered key roles for the mammalian Hippo kinases, Mst1/2, in driving appropriate immune ...
Jiali Cheng, Yukai Jing, Danqing Kang, Lu Yang, Jingwen Li, Ze Yu, Zican Peng, Xingbo Li, Yin Wei, Quan Gong, Quan Gong, Richard J. Miron, Yufeng Zhang, Chaohong Liu   +13 more
doaj   +1 more source

LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer [PDF]

, 2019
Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here,
Fukushima, Kohshiro, Fukuzawa, Moe, Longmore, Gregory D, Mukai, Satomi, Naito, Yoko, Nojima, Hiroshi, Nozaki, Masami, Okamoto, Ayumi, Sasakura, Towa, Yabuta, Norikazu   +9 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Ecofeminism and Cultural-Value System in Traditional Paddy Farming: A Folklore from West Borneo

Celt: A Journal of Culture, English Language Teaching & Literature
Ne’ Balungkur represents the inherited living value of traditional paddy farming lived by Dayak Kanayatn. Concerning the ecofeminism ideology, this study aims to reveal the existence of women and nature in traditional paddy farming in Ne’ Balungkur ...
Antonius Setyawan Sugeng Nur Agung, Monika Widyastuti Surtikanti, Wedhowerti Wedhowerti   +2 more
doaj   +1 more source

Hippo signalling during development [PDF]

Development, 2019
ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’
John Robert Davis, Nicolas Tapon
openaire   +3 more sources

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Mood Disorder Severity and Subtype Classification Using Multimodal Deep Neural Network Models

Sensors
The subtype diagnosis and severity classification of mood disorder have been made through the judgment of verified assistance tools and psychiatrists.
Joo Hun Yoo, Harim Jeong, Ji Hyun An, Tai-Myoung Chung   +3 more
doaj   +1 more source

Scholarship and Ministry in the Life and Thought of Augustine [PDF]

, 2011
Augustine is frequently recognized as one of the greatest Christian theologians in all of church history. His influence extends to both Protestant and Catholic circles, and his numerous theological works are still referenced by today\u27s students of ...
Thornhill, Anthony C.
core   +1 more source