Results 61 to 70 of about 56,542 (314)

Using Big Data analytics tool to influence decision-making in higher education: A case of South African Technical and Vocational Education and Training colleges

South African Journal of Information Management, 2022
Background: Big data analytics in education is a new concept that has the potential to change the decision-making landscape in South African Colleges. Higher institutions of learning, including Technical and Vocation Education Training (TVET) colleges ...
Kleinbooi T. Selowa, Appolonia I. Ilorah, Sello N. Mokwena   +2 more
doaj   +1 more source

Epithelial to mesenchymal transition in breast cancer : a novel murine model system and the regulatory role of tead transcription factors [PDF]

, 2012
Cancer is a leading cause of death worldwide, accounting for 7.6 million, or ~13% of all deaths in 2008. The majority of cancers arise from epithelia. Breast cancer, originating from the mammary epithelium, is the most frequent cancer in women worldwide.
Waldmeier, Lorenz
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Activity and Pool Use in Relation to Temperature and Water Changes in Zoo Hippopotamuses (Hippopotamus amphibious)

Animals, 2020
In the wild, hippopotamuses spend much of their daily activity in the water. In zoos, it is less clear the extent to which hippos spend time in the water.
Eduardo J. Fernandez, Martin Ramirez, Nancy C. Hawkes   +2 more
doaj   +1 more source

In vivo investigation of component-specific functions of the Hippo pathway [PDF]

The Hippo pathway is a kinase signalling cascade involved in the regulation of organ size, tissue homeostasis, and stem cell proliferation. Dysfunction of this pathway is associated with carcinogenesis, fibrosis, and defects in development and ...
Riley, Susanna Elizabeth
core   +1 more source

The Hippo pathway mediates Semaphorin signaling [PDF]

, 2022
Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Yang, Di, Luo, Min, Fu, Vivian, Yeoman, Benjamin, Diao, Yarui, Lin, Kimberly C, Wang, Ying, Giancotti, Filippo G., Ren, Bing, Lin, Kimberly C., Li, Fu-Long, Ma, Xiaoxiao, Engler, Adam J., Qiu, Yunjiang, Guan, Kun-Liang, Engler, Adam J, Meng, Zhipeng, Fang, Cao, Cai, Xiaomin, Giancotti, Filippo G   +19 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Estratégias competitivas no setor supermercadista: estudo de caso do Hippo supermercados [PDF]

, 2008
TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.O presente trabalho aborda o estudo das estratégias competitivas, tendo como objeto de análise o Hippo Supermercados, de Florianópolis, Santa Catarina.
Britto, Maria Helena José
core  

Mechanisms of Hippo pathway regulation [PDF]

, 2016
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years. The core of the Hippo pathway consists of
Moroishi, Toshiro, Guan, Kun-Liang, Meng, Zhipeng   +2 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source