Results 71 to 80 of about 114,310 (305)
Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. [PDF]
, 2020 Cyclin-dependent kinase 7 (CDK7) is a protein kinase that plays a major role in transcription initiation. Yes-associated protein (YAP) is a main effector of the Hippo/YAP signalling pathway.
Bin, Hu +12 more
core
Intestinal epithelial cell-intrinsic deletion of Setd7 identifies role for developmental pathways in immunity to helminth infection [PDF]
, 2016 The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems.
Antignano, Frann +7 more
core +4 more sources
Advanced Healthcare Materials, EarlyView.This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess +3 more
wiley +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
YAP and the Hippo pathway in pediatric cancer
Molecular & Cellular Oncology, 2017 The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis. It is evolutionarily conserved in mammals and is stimulated by cell–cell contact, inhibiting cell proliferation in response to increased cell density ...
Atif A. Ahmed +4 more
doaj +1 more source
Functional interplay between the Hippo pathway and heavy metals
Molecular & Cellular Oncology, 2022 Emerging studies highlight the Hippo pathway as an important player in organ size control, tissue homeostasis, regeneration, development, and diseases, but our understanding of its roles and regulations remains incomplete.
Han Han +3 more
doaj +1 more source
Preferences for and comprehension of original and readability-adapted materials [PDF]
, 1986 Running title: Preferences and comprehensionIncludes bibliographical references (leaves 41-42)Performed pursuant to contract no.
Green, Georgia M., Olsen, Margaret S.
core
Taming the Hippo: Raf-1 Controls Apoptosis by Suppressing MST2/Hippo [PDF]
Cell Cycle, 2005 The Raf-1 kinase has a well established role in activating the MEK-ERK/MAPK pathway. However, accumulating evidence including the phenotype of Raf-1(-/-) mice suggested that Raf-1 may have other functions independent of its role as MEK activator, in particular pertaining to protection against apoptosis. We have recently demonstrated a new role of Raf-1
Eric, O'Neill, Walter, Kolch
openaire +2 more sources
Advanced Science, EarlyView.Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun +7 more
wiley +1 more source
YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response
Frontiers in Immunology, 2020 YAP is a transcriptional coactivator of the Hippo signaling pathway that has largely been studied for its role in the regulation of organ size during development.
Andriana Lebid +3 more
doaj +1 more source