Results 71 to 80 of about 46,422 (268)

Chest wall restriction device for modeling respiratory challenges and dysfunction

Frontiers in Medical Engineering
Breathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues, Lizuannette Mejia, Rafael G. Zucchi, Paul W. Davenport, Nicholas J. Napoli   +4 more
doaj   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Emerging Artificial Intelligence in Mathematics Education: A Systematic Literature Review

Journal of Learning for Development
The Artificial Intelligence (AI) revolution has affected all of education, inluding mathematics education. Studies on AI have described how it can be integrated into mathematics learning.
Siti Suprihatiningsih, Gusti Uripno, Imam Sujadi, Rizki Kurniawan Rangkuti   +3 more
doaj   +1 more source

Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension

Clinical and Experimental Hypertension, 2019
Objective: To investigate the effects of angiotensin-converting enzyme 2 (ACE2) activation on pulmonary arterial cell apoptosis during pulmonary vascular remodeling associated with pulmonary arterial hypertension (PAH) and to elucidate potential ...
Daole Yan, Gang Li, Yaozhong Zhang, Yinglong Liu   +3 more
doaj   +1 more source

Two-signal requirement for growth-promoting function of Yap in hepatocytes

eLife, 2015
The transcriptional coactivator Yes-associated protein (Yap) promotes proliferation and inhibits apoptosis, suggesting that Yap functions as an oncogene. Most oncogenes, however, require a combination of at least two signals to promote proliferation.
Tian Su, Tanya Bondar, Xu Zhou, Cuiling Zhang, Hang He, Ruslan Medzhitov   +5 more
doaj   +1 more source

Hippo cannibalism

Biodiversity Observations, 2019
Hippo cannibalism was observed at Mandavu reservoir in Hwange National Park, Zimbabwe.
Julio J. De Castro, Mabel De Castro, Julio J. De Castro, Patricia Ruiz Teixidor   +3 more
openaire   +2 more sources

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Caranx hippos

, 2014
□ Caranx hippos (Linnaeus, 1766) – Crevalle jack; Xareu-macoa ①, ②, Charéu or Encharéu-denatura ...
Carneiro, Miguel, Martins, Rogélia, Landi, Monica, Costa, Filipe O.   +3 more
openaire   +2 more sources