Results 71 to 80 of about 56,542 (314)
G3: Genes, Genomes, Genetics, 2017 A gain-of-function mutation in the tyrosine kinase JAK2 (JAK2V617F) causes human myeloproliferative neoplasms (MPNs). These patients present with high numbers of myeloid lineage cells and have numerous complications.
Abigail M. Anderson +4 more
doaj +1 more source
, 2016 <p>Format the code entrance and give a clear README.md</p ...
Super-Hippo (5276644), Super-Hippo
core +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang +17 more
wiley +1 more source
Ecofeminism and Cultural-Value System in Traditional Paddy Farming: A Folklore from West Borneo
Celt: A Journal of Culture, English Language Teaching & LiteratureNe’ Balungkur represents the inherited living value of traditional paddy farming lived by Dayak Kanayatn. Concerning the ecofeminism ideology, this study aims to reveal the existence of women and nature in traditional paddy farming in Ne’ Balungkur ...
Antonius Setyawan Sugeng Nur Agung +2 more
doaj +1 more source
The Role of Mst1 in Lymphocyte Homeostasis and Function
Frontiers in Immunology, 2018 The Hippo pathway is an evolutionarily conserved pathway crucial for regulating tissue size and for limiting cancer development. However, recent work has also uncovered key roles for the mammalian Hippo kinases, Mst1/2, in driving appropriate immune ...
Jiali Cheng +13 more
doaj +1 more source
Possible Future Avenues for Rheumatoid Arthritis Therapeutics: Hippo Pathway
, 2023 Tao Wang,1,2 Zhandong Wang,1 Wenxia Qi,1 Ganggang Jiang,1 Gang Wang2 1Gansu University of Chinese Medicine, Lanzhou, 730020, People’s Republic of China; 2Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, 730020, People’s Republic of ...
Jiang G, Wang T, Qi W, Wang G, Wang Z
core
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Chest wall restriction device for modeling respiratory challenges and dysfunction
Frontiers in Medical EngineeringBreathing relies on unrestricted movement of the chest wall to maintain O2 and CO2 balance. Understanding the effects of chest and abdominal restrictions on respiratory function is critical for studying conditions such as respiratory diseases, extreme ...
Victoria Ribeiro Rodrigues +4 more
doaj +1 more source
A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase
Advanced Science, EarlyView.Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol +18 more
wiley +1 more source
Mood Disorder Severity and Subtype Classification Using Multimodal Deep Neural Network Models
SensorsThe subtype diagnosis and severity classification of mood disorder have been made through the judgment of verified assistance tools and psychiatrists.
Joo Hun Yoo +3 more
doaj +1 more source