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Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors. [PDF]
Cell Biol IntJiamvoraphong N +8 more
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Sugar defeats the Hippo: Glycogen regulation of the Hippo pathway in liver
Molecular Cell, 2021Liver glycogen is famous for glucose storage, but new work by Liu et al. (2021) now reveals that it's been hiding a few secrets and can directly promote liver enlargement and tumorigenesis by sequestering the tumor-suppressive Hippo signaling pathway.
Anh Thu, Nguyen-Lefebvre +2 more
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Immuno-hippo: Research progress of the hippo pathway in autoimmune disease
Immunology Letters, 2021Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis.
Paipai, Guo +6 more
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Proceedings of the VLDB Endowment, 2022
Hyper-parameter optimization is crucial for pushing the accuracy of a deep learning model to its limits. However, a hyper-parameter optimization job, referred to as a study, involves numerous trials of training a model using different training knobs, and therefore is very computation-heavy, typically taking hours and days to finish.
Ahnjae Shin +4 more
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Hyper-parameter optimization is crucial for pushing the accuracy of a deep learning model to its limits. However, a hyper-parameter optimization job, referred to as a study, involves numerous trials of training a model using different training knobs, and therefore is very computation-heavy, typically taking hours and days to finish.
Ahnjae Shin +4 more
openaire +1 more source
The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Journal of Cellular Physiology, 2020AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg +5 more
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Anti-Cancer Drugs, 2017
The Hippo pathway has generated considerable interest in recent years because of its involvement in several key hallmarks of cancer progression and metastasis. Research on the Hippo signaling pathway in cancer has been used to determine the activity of yes-associated protein (YAP) in tumorigenesis and disease progression.
Jingwen, Cao, Wenlong, Huang
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The Hippo pathway has generated considerable interest in recent years because of its involvement in several key hallmarks of cancer progression and metastasis. Research on the Hippo signaling pathway in cancer has been used to determine the activity of yes-associated protein (YAP) in tumorigenesis and disease progression.
Jingwen, Cao, Wenlong, Huang
openaire +2 more sources
The Hippo Pathway: Biology and Pathophysiology
Annual Review of Biochemistry, 2019 The Hippo pathway was initially discovered in as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, and regeneration.
Shenghong Ma +2 more
exaly +2 more sources