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Hippo Signaling in the Immune System
Trends in Biochemical Sciences, 2018Hippo signaling has a pivotal role in organ size control, tissue regeneration, and cancer. Recent studies have demonstrated critical functions of Hippo signaling in cancer immunity, innate immune responses against pathogens, and autoimmune diseases, refreshing our understanding of the implications of this pathway in the context of disease and therapy ...
Yuchao, Zhang, Haitao, Zhang, Bin, Zhao
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The unfolding of the Hippo signaling pathway
Developmental Biology, 2022The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ. At the turn of the 21st century, comprehensive genetic screens in model organisms had successfully uncovered the major signaling pathways that ...
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Hippo signaling in regeneration and aging
Mechanisms of Ageing and Development, 2020The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage.
Dana, Elster, Björn, von Eyss
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The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Journal of Cellular Physiology, 2020AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg +5 more
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Roles of Hippo signaling in lung cancer
Indian Journal of Cancer, 2015Lung cancer is the leading cause of cancer-related mortality in the world, with more than 1 million deaths/year. Over the past years, lung cancer treatment has been based on cytotoxic agents and an improvement in the outcome and quality of life for patients has been observed.
Y, Wang +5 more
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Hippo signaling in oval cells and hepatocarcinogenesis
Cancer Letters, 2011Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer mortality world wide. Despite continuing development of new therapies, the prognosis for patients with HCC remains extremely poor. In part, this may relate to molecular abnormalities that stimulate HCC tumorigenesis and also contribute to reduced
Tongsen, Zheng +3 more
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Science Signaling, 2015
Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Structural Insights into the Regulation of Hippo Signaling
ACS Chemical Biology, 2017During development, the Hippo pathway regulates the balance between cell proliferation and apoptosis to control organ size. Appropriate Hippo signaling is associated with stem cell maintenance, while inappropriate signaling can result in tumorigenesis and cancer.
Leah Cairns +2 more
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Reconstructing the Hippo signaling network
Science Bulletin, 2023Zhenxing, Zhong +2 more
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Hippo signalling in intestinal regeneration and cancer
Current Opinion in Cell Biology, 2017The Hippo pathway is a unique signalling module that regulates cell-specific transcriptional responses and responds to a wide range of intrinsic and extrinsic cues. Besides its classical role in restricting tissue size during development, Hippo signalling is now recognized to control numerous processes including cell proliferation, survival, cell fate ...
Alex, Gregorieff, Jeffrey L, Wrana
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