Results 231 to 240 of about 60,559 (303)

Structural analysis of Cu/Zn‐superoxide dismutase linked to neurodegenerative disease by antibody‐guided cryo‐EM

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Accumulation of misfolded proteins is a hallmark of many neurodegenerative diseases. To characterize such misfolded species in vivo, conformation‐specific antibodies are widely used; however, limited knowledge of antibody–epitope interactions often hampers mechanistic insight.
Yuki Shino, Norifumi Muraki, Yui Kobatake, Hiroaki Kamishina, Hirofumi Kosuge, Makoto Nakakido, Kouhei Tsumoto, Yoshiaki Furukawa   +7 more
wiley   +1 more source

FAM189A2 activates Hippo signaling pathway by abrogating WWP2-mediated LATS1 ubiquitination, to inhibit the glycolysis and proliferation processes of lung adenocarcinoma. [PDF]

J Transl Med
Chen B, Rong X, Feng Y, Hou Y, Fu L, Han Q, Song Y, Lin X.   +7 more
europepmc   +1 more source

Heterokairic Genes and the Eco‐Evo‐Devo of Timing

Evolution &Development, Volume 28, Issue 2, June 2026.
Heterokairic genes as the bridge (Heterokairic Pathways?): Heterokairic genes are heterochronic regulators whose activity is modulated by environmental conditions. External cues (e.g., temperature, nutrition, oxygen, density: yellow box) are sensed (yellow arrows) and converted into endocrine and metabolic signals (purple box and arrow into fish's ...
Leandro Lofeu, Ehsan Pashay Ahi
wiley   +1 more source

An Inhibitor of Death-Associated Protein Kinase 3 (DAPK3) Disrupts Hippo Signaling and Intestinal Epithelial Regeneration in Murine DSS-Induced Colitis. [PDF]

Dig Dis Sci
Chen HM, Carlson DA, Haystead TAJ, MacDonald JA.   +3 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, Volume 20, Issue 5, Page 1284-1298, May 2026.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway. [PDF]

Inflammation
Xue X, Gao F, Chen J, Wang M, Wu X, Liao H, Sun Z, Nie S.   +7 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, Volume 16, Issue 5, Page 870-884, May 2026.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma. [PDF]

Cell Death Discov
Liu J, Liang X, Wang K, Zhang C, Li C, Zhao L, Kuang Y, Wang M, Liu J, Zhou L, Ma L.   +10 more
europepmc   +1 more source

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis. [PDF]

Stem Cell Res Ther
Suzuki T, Susa K, Kikuchi H, Nakano Y, Yanagi T, Hara Y, Fujiki T, Ando F, Mandai S, Mori Y, Mori T, Iwasa H, Hata Y, Uchida S, Sohara E.   +14 more
europepmc   +1 more source