Results 231 to 240 of about 36,476 (254)
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The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Journal of Cellular Physiology, 2020AbstractOsteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation of cellular functions.
Emel Rothzerg +5 more
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Hippo signaling in oval cells and hepatocarcinogenesis
Cancer Letters, 2011Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer mortality world wide. Despite continuing development of new therapies, the prognosis for patients with HCC remains extremely poor. In part, this may relate to molecular abnormalities that stimulate HCC tumorigenesis and also contribute to reduced
Tongsen, Zheng +3 more
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Roles of Hippo signaling in lung cancer
Indian Journal of Cancer, 2015Lung cancer is the leading cause of cancer-related mortality in the world, with more than 1 million deaths/year. Over the past years, lung cancer treatment has been based on cytotoxic agents and an improvement in the outcome and quality of life for patients has been observed.
Y, Wang +5 more
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Science Signaling, 2015
Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Hypoxia suppresses the Hippo pathway, reinforcing the stabilization of HIF-1α under low oxygen conditions.
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Reconstructing the Hippo signaling network
Science Bulletin, 2023Zhenxing, Zhong +2 more
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Structural Insights into the Regulation of Hippo Signaling
ACS Chemical Biology, 2017During development, the Hippo pathway regulates the balance between cell proliferation and apoptosis to control organ size. Appropriate Hippo signaling is associated with stem cell maintenance, while inappropriate signaling can result in tumorigenesis and cancer.
Leah Cairns +2 more
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Hippo signalling in intestinal regeneration and cancer
Current Opinion in Cell Biology, 2017The Hippo pathway is a unique signalling module that regulates cell-specific transcriptional responses and responds to a wide range of intrinsic and extrinsic cues. Besides its classical role in restricting tissue size during development, Hippo signalling is now recognized to control numerous processes including cell proliferation, survival, cell fate ...
Alex, Gregorieff, Jeffrey L, Wrana
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Hippo signaling in mammalian stem cells
Seminars in Cell & Developmental Biology, 2012Over the past decade, the Hippo signaling cascade has been linked to organ size regulation in mammals. Indeed, modulation of the Hippo pathway can have potent effects on cellular proliferation and/or apoptosis and a deregulation of the pathway often leads to tumor development. Importantly, emerging evidence indicates that the Hippo pathway can modulate
Annie M, Tremblay, Fernando D, Camargo
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Hippo signalling directs intestinal fate
Nature Cell Biology, 2014Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and ...
le Bouteiller, Marie Catherine M +1 more
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Hippo Signaling in the Ovary: Emerging Roles in Development, Fertility, and Disease
Endocrine Reviews, 2022Kendra L Clark +2 more
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