Results 221 to 230 of about 36,476 (254)

LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma. [PDF]

Cell Death Discov
Liu J, Liang X, Wang K, Zhang C, Li C, Zhao L, Kuang Y, Wang M, Liu J, Zhou L, Ma L.   +10 more
europepmc   +1 more source

Ewing sarcoma depends on C4orf48/NICOL, a NELL2 cofactor regulated by Hippo signaling. [PDF]

Cell Signal
Jayabal P, Ma X, Chen Y, Yuan Y, Shiio Y.   +4 more
europepmc   +1 more source

iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis. [PDF]

Stem Cell Res Ther
Suzuki T, Susa K, Kikuchi H, Nakano Y, Yanagi T, Hara Y, Fujiki T, Ando F, Mandai S, Mori Y, Mori T, Iwasa H, Hata Y, Uchida S, Sohara E.   +14 more
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TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression. [PDF]

Adv Sci (Weinh)
Fu L, Liao W, Tan Y, Lin H, Ye K, Zhou X, Lin M, Huang K, Chen M, Wei J, Feng H, Chen Y, Chen J, Guan B, Li S, Zhang Z, Yu A, Feng Z, Zhang L, Shu G, Lu J, Chen W, Pan Y, Yang J, Luo J, Luo L.   +25 more
europepmc   +1 more source

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Regulation of Hippo Signaling by Mechanical Signals and the Cytoskeleton

DNA and Cell Biology, 2020
Hippo signaling regulates the balance between cell proliferation and apoptosis to control the size of organs during development. Appropriate Hippo signaling is associated with stem cell differentiation, and inappropriate signaling can result in tumorigenesis and cancer.
Cong Zhang, Jiawei Gao, Xiao-Tao Wu
exaly   +3 more sources

The Hippo Signaling Pathway in Development and Disease [PDF]

Developmental Cell, 2019
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future ...
Yonggang Zheng, Duojia Pan
exaly   +3 more sources

The unfolding of the Hippo signaling pathway

Developmental Biology, 2022
The development of a functional organ requires not only patterning mechanisms that confer proper identities to individual cells, but also growth-regulatory mechanisms that specify the final size of the organ. At the turn of the 21st century, comprehensive genetic screens in model organisms had successfully uncovered the major signaling pathways that ...
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Hippo signaling in regeneration and aging

Mechanisms of Ageing and Development, 2020
The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage.
Dana, Elster, Björn, von Eyss
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Modularity in the Hippo signaling pathway

Trends in Biochemical Sciences, 2010
Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
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Hippo Signaling in the Immune System

Trends in Biochemical Sciences, 2018
Hippo signaling has a pivotal role in organ size control, tissue regeneration, and cancer. Recent studies have demonstrated critical functions of Hippo signaling in cancer immunity, innate immune responses against pathogens, and autoimmune diseases, refreshing our understanding of the implications of this pathway in the context of disease and therapy ...
Yuchao, Zhang, Haitao, Zhang, Bin, Zhao
openaire   +2 more sources