Results 221 to 230 of about 36,582 (254)

Caveolin-2 Knockdown Alleviated Sepsis-induced Acute Lung Injury Via Promoting Macrophage M2 Polarization and Inhibiting Apoptosis by Hippo Signaling Pathway. [PDF]

Inflammation
Xue X, Gao F, Chen J, Wang M, Wu X, Liao H, Sun Z, Nie S.   +7 more
europepmc   +1 more source

LINC01198 activates Hippo signaling to stimulate IL-1β autocrine for driving vemurafenib resistance by associating with TAOK1/2 in melanoma. [PDF]

Cell Death Discov
Liu J, Liang X, Wang K, Zhang C, Li C, Zhao L, Kuang Y, Wang M, Liu J, Zhou L, Ma L.   +10 more
europepmc   +1 more source

iPSC-based drug discovery identified the Hippo signaling pathway as a therapeutic target in the fibrosis of NPHP1-deficient nephronophthisis. [PDF]

Stem Cell Res Ther
Suzuki T, Susa K, Kikuchi H, Nakano Y, Yanagi T, Hara Y, Fujiki T, Ando F, Mandai S, Mori Y, Mori T, Iwasa H, Hata Y, Uchida S, Sohara E.   +14 more
europepmc   +1 more source

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression. [PDF]

Adv Sci (Weinh)
Fu L, Liao W, Tan Y, Lin H, Ye K, Zhou X, Lin M, Huang K, Chen M, Wei J, Feng H, Chen Y, Chen J, Guan B, Li S, Zhang Z, Yu A, Feng Z, Zhang L, Shu G, Lu J, Chen W, Pan Y, Yang J, Luo J, Luo L.   +25 more
europepmc   +1 more source

Hippo Signaling in the Endometrium

International Journal of Molecular Sciences, 2022
The uterus is essential for embryo implantation and fetal development. During the estrous cycle, the uterine endometrium undergoes dramatic remodeling to prepare for pregnancy. Angiogenesis is an essential biological process in endometrial remodeling. Steroid hormones regulate the series of events that occur during such remodeling.
Kwonho Hong, Hyuk Song, Youngsok Choi
exaly   +3 more sources

Hippo Signaling Pathway in Gliomas [PDF]

Cells, 2021
The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Lucie Karayan Tapon, Pierre-Olivier Guichet, Konstantin Masliantsev   +2 more
exaly   +4 more sources

Hippo Signaling in Embryogenesis and Development

Trends in Biochemical Sciences, 2021
Hippo pathway components are structurally and functionally conserved and are notable for their role in controlling organ size. More diverse functions of the Hippo pathway have been recognized, including development, tissue homeostasis, wound healing and regeneration, immunity, and tumorigenesis.
Kun-Liang Guan
exaly   +4 more sources

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Regulation of Hippo Signaling by Mechanical Signals and the Cytoskeleton

DNA and Cell Biology, 2020
Hippo signaling regulates the balance between cell proliferation and apoptosis to control the size of organs during development. Appropriate Hippo signaling is associated with stem cell differentiation, and inappropriate signaling can result in tumorigenesis and cancer.
Cong Zhang, Xiaotao Wu, Jiawei Gao
exaly   +3 more sources

The Hippo Signaling Pathway in Development and Disease [PDF]

Developmental Cell, 2019
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future ...
Yonggang Zheng, Duojia Pan
exaly   +3 more sources

Modularity in the Hippo signaling pathway

Trends in Biochemical Sciences, 2010
Metazoans have evolved several pathways to regulate the size of organs and ultimately that of organisms. One such pathway is known as Salvador-Warts-Hippo, or simply Hippo. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network.
Marius, Sudol, Kieran F, Harvey
openaire   +2 more sources