Results 51 to 60 of about 36,582 (254)

Zyxin links fat signaling to the hippo pathway.

PLoS Biology, 2011
The Hippo signaling pathway has a conserved role in growth control and is of fundamental importance during both normal development and oncogenesis. Despite rapid progress in recent years, key steps in the pathway remain poorly understood, in part due to ...
Cordelia Rauskolb, Guohui Pan, B V V G Reddy, Hyangyee Oh, Kenneth D Irvine   +4 more
doaj   +1 more source

Hippo dictates signaling for cellular homeostasis and immune defense in Crassostrea hongkongensis hemocytes

Frontiers in Immunology, 2023
IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao, Fan Mao, Xiaoying Zheng, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Wenjie Yi, Jingchen Song, Jingchen Song, Jingchen Song, Shiwei Fu, Shiwei Fu, Shiwei Fu, Zhiming Xiang, Zhiming Xiang, Shu Xiao, Shu Xiao, Yongbo Bao, Ziniu Yu, Ziniu Yu, Yang Zhang, Yang Zhang   +21 more
doaj   +1 more source

Hippo signaling: growth control and beyond [PDF]

Development, 2011
The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the ...
Halder, Georg, Johnson, Randy L.
openaire   +2 more sources

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Hippo signaling in organ size control [PDF]

Genes & Development, 2007
The control of organ (or organism) size is a fundamental aspect of life that has long captured human imagination. What makes an elephant grow a million times larger than a mouse? How do our two hands develop independently of each other yet reach very similar size? How does a liver precisely regenerate its original mass when two-thirds of it is removed?
openaire   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Hippo Signaling in Cancer: Lessons From Drosophila Models

Frontiers in Cell and Developmental Biology, 2019
Hippo pathway was initially identified through genetic screens for genes regulating organ size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key regulator of homeostasis, and in tumorigenesis.
Kirti Snigdha, Karishma Sanjay Gangwani, Gauri Vijay Lapalikar, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh   +10 more
doaj   +1 more source

Hippo Signaling Goes Long Range [PDF]

Cell, 2012
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular ...
Codelia, Veronica A., Irvine, Kenneth D.   +1 more
openaire   +2 more sources

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Role of Hippo signaling in regulating immunity [PDF]

Cellular & Molecular Immunology, 2018
The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-
Lixin Hong, Xun Li, Dawang Zhou, Jing Geng, Lanfen Chen   +4 more
openaire   +2 more sources