Results 31 to 40 of about 36,582 (254)

Hippo signaling: to die or not to die [PDF]

Cell Death & Differentiation, 2013
In this issue of CDD, Reuven et al.1 provide an elegant mechanism by which LATS2, a core component of the Hippo pathway, impedes DNA damage-induced apoptosis through inhibition of c-Abl. By dissecting signaling events upon γ-irradiation of sparse and dense cell, the authors revealed a dialogue between Hippo signaling members and DNA damage response ...
openaire   +2 more sources

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source

Phase separation of Hippo signalling complexes

The EMBO Journal, 2023
Abstract The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase is activated by
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson   +9 more
openaire   +2 more sources

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

Targeting Hippo-YAP/TAZ signaling pathway: an updated review demonstrating the therapeutic potential of key plant derived anticancer compounds

Frontiers in Pharmacology
A signaling mechanism that has persisted through evolution, the Hippo pathway is involved in the development and progression of many different types of cancer.
Deena Elsori, Pratibha Pandey, Kholoud Alshaikh, Ali G. Alkhathami, Mohd Saeed, Ajay Singh, Fahad Khan   +6 more
doaj   +1 more source

Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders?

Frontiers in Psychiatry, 2018
Discovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration.
Jens Stepan, Elmira Anderzhanova, Nils C. Gassen   +2 more
doaj   +1 more source

Hippo signaling in the kidney: the good and the bad [PDF]

American Journal of Physiology-Renal Physiology, 2016
The Hippo signaling pathway is an evolutionarily conserved kinase cascade, playing multiple roles in embryonic development that controls organ size, cell proliferation, and apoptosis. At the center of this network lie the Hippo kinase target and downstream pathway effector Yes-associated protein (YAP) and its paralog TAZ.
Jenny S, Wong, Kristin, Meliambro, Justina, Ray, Kirk N, Campbell   +3 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Premetazoan Origin of the Hippo Signaling Pathway

Cell Reports, 2012
Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa ...
Sebé Pedrós, Arnau, Zheng, Yonggang, Ruiz Trillo, Iñaki, Pan, Duojia   +3 more
openaire   +5 more sources

The Hippo Signaling Pathway in Pancreatic Cancer [PDF]

Anticancer Research, 2019
Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer. YES-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the two major downstream effectors of the Hippo pathway ...
Daniel, Ansari, Henrik, Ohlsson, Carl, Althini, Monika, Bauden, Qimin, Zhou, Dingyuan, Hu, Roland, Andersson   +6 more
openaire   +2 more sources