Results 31 to 40 of about 36,476 (254)

The Hippo signaling pathway in gastric cancer

Acta Biochimica et Biophysica Sinica, 2023
Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer-associated death worldwide. The Hippo signaling pathway plays crucial roles in organ size control and tissue homeostasis under physiological conditions, yet its aberrations ...
Cao Zhifa, An Liwei, Han Yi, Jiao Shi, Zhou Zhaocai   +4 more
openaire   +3 more sources

The Hippo pathway mediates Semaphorin signaling [PDF]

Science Advances, 2022
Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng, Fu-Long Li, Cao Fang, Benjamin Yeoman, Yunjiang Qiu, Ying Wang, Xiaomin Cai, Kimberly C. Lin, Di Yang, Min Luo, Vivian Fu, Xiaoxiao Ma, Yarui Diao, Filippo G. Giancotti, Bing Ren, Adam J. Engler, Kun-Liang Guan   +16 more
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FoxO6 regulates Hippo signaling and growth of the craniofacial complex.

PLoS Genetics, 2018
The mechanisms that regulate post-natal growth of the craniofacial complex and that ultimately determine the size and shape of our faces are not well understood. Hippo signaling is a general mechanism to control tissue growth and organ size, and although
Zhao Sun, Clarissa S G da Fontoura, Myriam Moreno, Nathan E Holton, Mason Sweat, Yan Sweat, Myoung Keun Lee, Jed Arbon, Felicitas B Bidlack, Daniel R Thedens, Peggy Nopoulos, Huojun Cao, Steven Eliason, Seth M Weinberg, James F Martin, Lina Moreno-Uribe, Brad A Amendt   +16 more
doaj   +1 more source

USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis

Cell Death and Disease, 2023
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu, Quanhui Li, Yifeng Zang, Xin Li, Zhongbo Li, Peng Zhang, Chang Feng, Penghe Yang, Jiayao Cui, Yanan Sun, Tian Wei, Peng Su, Xin Zhao, Huijie Yang, Yinlu Ding   +14 more
doaj   +1 more source

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

eLife, 2015
The Hippo pathway controls tissue growth through a core kinase cascade that impinges on the transcription of growth-regulatory genes. Understanding how this pathway is regulated in development remains a major challenge.
Hua Deng, Wei Wang, Jianzhong Yu, Yonggang Zheng, Yun Qing, Duojia Pan   +5 more
doaj   +1 more source

Phase separation of Hippo signalling complexes

The EMBO Journal, 2023
Abstract The Hippo pathway was originally discovered to control tissue growth in Drosophila and includes the Hippo kinase (Hpo; MST1/2 in mammals), scaffold protein Salvador (Sav; SAV1 in mammals) and the Warts kinase (Wts; LATS1/2 in mammals). The Hpo kinase is activated by
Teresa T Bonello, Danfeng Cai, Georgina C Fletcher, Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange, Zhe Liu, Jennifer Lippincott‐Schwartz, Jennifer M Kavran, Barry J Thompson   +9 more
openaire   +2 more sources

Hippo signaling: to die or not to die [PDF]

Cell Death & Differentiation, 2013
In this issue of CDD, Reuven et al.1 provide an elegant mechanism by which LATS2, a core component of the Hippo pathway, impedes DNA damage-induced apoptosis through inhibition of c-Abl. By dissecting signaling events upon γ-irradiation of sparse and dense cell, the authors revealed a dialogue between Hippo signaling members and DNA damage response ...
openaire   +2 more sources

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

Hippo signaling in the kidney: the good and the bad [PDF]

American Journal of Physiology-Renal Physiology, 2016
The Hippo signaling pathway is an evolutionarily conserved kinase cascade, playing multiple roles in embryonic development that controls organ size, cell proliferation, and apoptosis. At the center of this network lie the Hippo kinase target and downstream pathway effector Yes-associated protein (YAP) and its paralog TAZ.
Jenny S, Wong, Kristin, Meliambro, Justina, Ray, Kirk N, Campbell   +3 more
openaire   +2 more sources

Hippo Signaling: Emerging Pathway in Stress-Related Psychiatric Disorders?

Frontiers in Psychiatry, 2018
Discovery of the Hippo pathway and its core components has made a significant impact on our progress in the understanding of organ development, tissue homeostasis, and regeneration.
Jens Stepan, Elmira Anderzhanova, Nils C. Gassen   +2 more
doaj   +1 more source