Results 11 to 20 of about 60,559 (303)
Hippo Signaling Pathway in Pancreas Development [PDF]
Frontiers in Cell and Developmental Biology, 2021 The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu +6 more
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GPCR-Hippo Signaling in Cancer [PDF]
Cells, 2019 The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
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Actin cytoskeleton regulates Hippo signaling. [PDF]
PLoS ONE, 2013 Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear.
Pradeep Reddy +3 more
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Hippo signaling pathway and respiratory diseases
Cell Death Discovery, 2022 The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration.
Weifeng Tang +7 more
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Hippo signaling in mammalian reproduction. [PDF]
ReproductionThe Hippo signaling pathway, so named for its massive overgrowth mutant phenotypes, has become one of the most exciting signaling pathways to emerge in the field of reproductive biology. While disruption of Hippo is associated with tumorigenesis in many organs and tissues, relatively less is understood about the normal roles of Hippo signaling in the ...
Kruger RE, Aziz F, Ralston A.
europepmc +3 more sources
Hippo Signaling Pathway in Gliomas [PDF]
Cells, 2021 The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Konstantin Masliantsev +2 more
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Hippo Signaling in the Endometrium
International Journal of Molecular Sciences, 2022 The uterus is essential for embryo implantation and fetal development. During the estrous cycle, the uterine endometrium undergoes dramatic remodeling to prepare for pregnancy. Angiogenesis is an essential biological process in endometrial remodeling. Steroid hormones regulate the series of events that occur during such remodeling.
Sohyeon Moon +8 more
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Hippo signalling during development [PDF]
Development, 2019 ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’
John Robert Davis, Nicolas Tapon
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The Hippo Signaling Pathway Interactome [PDF]
Science, 2013 Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young +6 more
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Cell Junctions in Hippo Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment.
Ruchan, Karaman, Georg, Halder
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