Results 11 to 20 of about 36,476 (254)
GPCR-Hippo Signaling in Cancer [PDF]
Cells, 2019 The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies
Jiaqian Luo, Fa-Xing Yu
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Actin cytoskeleton regulates Hippo signaling. [PDF]
PLoS ONE, 2013 Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear.
Pradeep Reddy +3 more
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The Hippo signaling pathway in development and regeneration
Cell ReportsSummary: The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics
Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu
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Hippo signaling in mammalian reproduction. [PDF]
ReproductionThe Hippo signaling pathway, so named for its massive overgrowth mutant phenotypes, has become one of the most exciting signaling pathways to emerge in the field of reproductive biology. While disruption of Hippo is associated with tumorigenesis in many organs and tissues, relatively less is understood about the normal roles of Hippo signaling in the ...
Kruger RE, Aziz F, Ralston A.
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Hippo Signaling in the Endometrium
International Journal of Molecular Sciences, 2022 The uterus is essential for embryo implantation and fetal development. During the estrous cycle, the uterine endometrium undergoes dramatic remodeling to prepare for pregnancy. Angiogenesis is an essential biological process in endometrial remodeling. Steroid hormones regulate the series of events that occur during such remodeling.
Sohyeon Moon +8 more
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Hippo Signaling Pathway in Gliomas [PDF]
Cells, 2021 The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Konstantin Masliantsev +2 more
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Hippo signaling at a glance [PDF]
Journal of Cell Science, 2010 How the organs of multicellular organisms develop to a pre-defined size is a fundamental question in biology, but little is known about the underlying mechanisms. In the past decade, the Hippo pathway has been revealed to play a crucial role in organ size control (reviewed by [Zhao et al., 2010a ...
Bin, Zhao, Li, Li, Kun-Liang, Guan
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The Hippo Signaling Pathway Interactome [PDF]
Science, 2013 Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young +6 more
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Hippo Signaling Pathway in Pancreas Development
Frontiers in Cell and Developmental Biology, 2021 The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu +6 more
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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