Results 21 to 30 of about 36,476 (254)
Cell Death and Disease, 2022 Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
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Structural dissection of Hippo signaling [PDF]
Acta Biochimica et Biophysica Sinica, 2015 The Hippo pathway controls cell number and organ size by restricting cell proliferation and promoting apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer.
Zhubing, Shi, Shi, Jiao, Zhaocai, Zhou
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Hippo Signaling in Embryogenesis and Development
Trends in Biochemical Sciences, 2021 Hippo pathway components are structurally and functionally conserved and are notable for their role in controlling organ size. More diverse functions of the Hippo pathway have been recognized, including development, tissue homeostasis, wound healing and regeneration, immunity, and tumorigenesis.
Zhengming, Wu, Kun-Liang, Guan
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Hippo signalling during development [PDF]
Development, 2019 ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’
John Robert Davis, Nicolas Tapon
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Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways
Frontiers in Cell and Developmental Biology, 2020 Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis.
Juan Carlos Duhart, Laurel A. Raftery
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Regulation of Hippo signalling by p38 signalling
Journal of Molecular Cell Biology, 2016 The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats.
Huang, Dashun +7 more
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Cell Junctions in Hippo Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment.
Ruchan, Karaman, Georg, Halder
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A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
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Hippo signaling pathway and respiratory diseases
Cell Death Discovery, 2022 The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration.
Weifeng Tang +7 more
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Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development
Frontiers in Cell and Developmental Biology, 2021 The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated.
Dorothee Bornhorst +3 more
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