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The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System
Frontiers in Immunology, 2020 The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration.
Jinbo Cheng +4 more
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Hippo signalling during development [PDF]
Development, 2019 ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g. the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’
John Robert Davis, Nicolas Tapon
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Regulation of Hippo signalling by p38 signalling
Journal of Molecular Cell Biology, 2016 The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats.
Huang, Dashun +7 more
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A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
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Cell Junctions in Hippo Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2017 The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment.
Ruchan, Karaman, Georg, Halder
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The Hippo pathway mediates Semaphorin signaling [PDF]
Science Advances, 2022 Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng +16 more
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USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis
Cell Death and Disease, 2023 Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu +14 more
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Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development
Frontiers in Cell and Developmental Biology, 2021 The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated.
Dorothee Bornhorst +3 more
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FoxO6 regulates Hippo signaling and growth of the craniofacial complex.
PLoS Genetics, 2018 The mechanisms that regulate post-natal growth of the craniofacial complex and that ultimately determine the size and shape of our faces are not well understood. Hippo signaling is a general mechanism to control tissue growth and organ size, and although
Zhao Sun +16 more
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The Hippo signaling pathway in gastric cancer
Acta Biochimica et Biophysica Sinica, 2023 Gastric cancer (GC) is an aggressive malignant disease which still lacks effective early diagnosis markers and targeted therapies, representing the fourth-leading cause of cancer-associated death worldwide. The Hippo signaling pathway plays crucial roles in organ size control and tissue homeostasis under physiological conditions, yet its aberrations ...
Cao Zhifa +4 more
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