Results 21 to 30 of about 60,559 (303)
Hippo signaling at a glance [PDF]
Journal of Cell Science, 2010 How the organs of multicellular organisms develop to a pre-defined size is a fundamental question in biology, but little is known about the underlying mechanisms. In the past decade, the Hippo pathway has been revealed to play a crucial role in organ size control (reviewed by [Zhao et al., 2010a ...
Bin, Zhao, Li, Li, Kun-Liang, Guan
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Structural dissection of Hippo signaling [PDF]
Acta Biochimica et Biophysica Sinica, 2015 The Hippo pathway controls cell number and organ size by restricting cell proliferation and promoting apoptosis, and thus is a key regulator in development and homeostasis. Dysfunction of the Hippo pathway correlates with many pathological conditions, especially cancer.
Zhubing, Shi, Shi, Jiao, Zhaocai, Zhou
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Cell Death and Disease, 2022 Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
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The Hippo pathway mediates Semaphorin signaling [PDF]
Science Advances, 2022 Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng +16 more
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The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System
Frontiers in Immunology, 2020 The Hippo signaling pathway, an evolutionarily conserved protein kinase cascade, plays a critical role in controlling organ size, cancer development, and tissue regeneration.
Jinbo Cheng +4 more
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Hippo Signaling Goes Long Range [PDF]
Cell, 2012 The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular ...
Codelia, Veronica A. +1 more
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Mob Family Proteins: Regulatory Partners in Hippo and Hippo-Like Intracellular Signaling Pathways
Frontiers in Cell and Developmental Biology, 2020 Studies in yeast first delineated the function of Mob proteins in kinase pathways that regulate cell division and shape; in multicellular eukaryotes Mobs regulate tissue growth and morphogenesis.
Juan Carlos Duhart, Laurel A. Raftery
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A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft Tissue Sarcomas
Frontiers in Oncology, 2015 The Hippo signaling pathway is an evolutionarily conserved developmental network vital for the regulation of organ size, tissue homeostasis, repair and regeneration, and cell fate. The Hippo pathway has also been shown to have tumor suppressor properties.
Michael D Deel +6 more
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Strong as a Hippo’s Heart: Biomechanical Hippo Signaling During Zebrafish Cardiac Development
Frontiers in Cell and Developmental Biology, 2021 The heart is comprised of multiple tissues that contribute to its physiological functions. During development, the growth of myocardium and endocardium is coupled and morphogenetic processes within these separate tissue layers are integrated.
Dorothee Bornhorst +3 more
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Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
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