Results 1 to 10 of about 36,582 (254)

KSR1 is a scaffold for the Hippo signaling pathway [PDF]

Communications Biology
The evolutionarily conserved Hippo signaling pathway regulates organ size and tissue homeostasis. Yes-associated protein (YAP) functions as a transcriptional co-activator and is a critical downstream effector of the Hippo signaling pathway.
Samar Sayedyahossein, Mohammed Rizwan Babu Sait, Zhigang Li, Riddhi Banerjee, Andy Tran, Louise Thines, Mehdi Karimi, Mehrnoosh Bahmani, Naomi Mishan, Pooya Borzou, Sergio A. Hassan, David B. Sacks   +11 more
doaj   +5 more sources

Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

MedComm, 2023
As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size.
Liemei Lv, Xiangxiang Zhou
exaly   +2 more sources

The Hippo signaling pathway as a therapeutic target in Alzheimer’s disease [PDF]

Molecular Neurodegeneration
The Hippo signaling pathway is well-known for its regulation of organ size, cell proliferation, apoptosis, and cell migration and differentiation. Recent studies have demonstrated that Hippo signaling also plays important roles in the nervous system ...
Doris Chen, Stella Wigglesworth-Littlewood, Frank J. Gunn-Moore   +2 more
doaj   +2 more sources

The Hippo signaling pathway modulates pancreatic tissue homeostasis [PDF]

Cell Death Discovery
The Hippo signaling pathway, a highly conserved signaling cascade from Drosophila to mammals, plays a critical role in mammals in regulating cell proliferation, senescence and apoptosis.
Xiaoyan Wang, Jiajing Du, Haiyun Li, Zhiwei Cao, Zhonghua Cheng, Zuoyun Wang   +5 more
doaj   +2 more sources

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

Microbiology Spectrum, 2023
White spot syndrome virus (WSSV) is a serious threat to shrimp aquaculture, especially Pacific white shrimp, Penaeus vannamei, the most farmed shrimp in the world.
Linwei Yang, Zi-Ang Wang, Ran Geng, Hengwei Deng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu   +8 more
doaj   +1 more source

A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration

Frontiers in Cell and Developmental Biology, 2020
Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques.
Madison Irwin, Meghana Tare, Aditi Singh, Oorvashi Roy Puli, Neha Gogia, Matthew Riccetti, Prajakta Deshpande, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh   +15 more
doaj   +1 more source

Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

eLife, 2020
Tissue homeostasis and regeneration in the Drosophila midgut is regulated by a diverse array of signaling pathways including the Hippo pathway. Hippo signaling restricts intestinal stem cell (ISC) proliferation by sequestering the transcription co-factor
Xue Hao, Shimin Wang, Yi Lu, Wentao Yu, Pengyue Li, Dan Jiang, Tong Guo, Mengjie Li, Jinhui Li, Jinjin Xu, Wenqing Wu, Margaret S Ho, Lei Zhang   +12 more
doaj   +1 more source

The critical role of the Hippo signaling pathway in kidney diseases

Frontiers in Pharmacology, 2022
The Hippo signaling pathway is involved in cell growth, proliferation, and apoptosis, and it plays a key role in regulating organ size, tissue regeneration, and tumor development.
Yuting Sun, De Jin, Ziwei Zhang, Di Jin, JiaoJiao Xue, LiYun Duan, YuQing Zhang, XiaoMin Kang, FengMei Lian, FengMei Lian   +9 more
doaj   +1 more source

Hippo Signaling Pathway in Pancreas Development

Frontiers in Cell and Developmental Biology, 2021
The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity.
Yifan Wu, Yifan Wu, Pauline Aegerter, Michael Nipper, Logan Ramjit, Jun Liu, Pei Wang   +6 more
doaj   +1 more source

Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Cell Death and Disease, 2022
Hippo signaling is a conserved mechanism for controlling organ growth. Increasing evidence suggests that Hippo signaling is modulated by various cellular factors for normal development and tumorigenesis.
Jung-Wan Mok, Kwang-Wook Choi
doaj   +1 more source