Results 1 to 10 of about 60,559 (303)

KSR1 is a scaffold for the Hippo signaling pathway. [PDF]

Commun Biol
The evolutionarily conserved Hippo signaling pathway regulates organ size and tissue homeostasis. Yes-associated protein (YAP) functions as a transcriptional co-activator and is a critical downstream effector of the Hippo signaling pathway.
Sayedyahossein S, Babu Sait MR, Li Z, Banerjee R, Tran A, Thines L, Karimi M, Bahmani M, Mishan N, Borzou P, Hassan SA, Sacks DB.   +11 more
europepmc   +2 more sources

The Hippo signaling pathway as a therapeutic target in Alzheimer's disease. [PDF]

Mol Neurodegener
The Hippo signaling pathway is well-known for its regulation of organ size, cell proliferation, apoptosis, and cell migration and differentiation. Recent studies have demonstrated that Hippo signaling also plays important roles in the nervous system ...
Chen D, Wigglesworth-Littlewood S, Gunn-Moore FJ.   +2 more
europepmc   +2 more sources

The Hippo signaling pathway modulates pancreatic tissue homeostasis. [PDF]

Cell Death Discov
The Hippo signaling pathway, a highly conserved signaling cascade from Drosophila to mammals, plays a critical role in mammals in regulating cell proliferation, senescence and apoptosis.
Wang X, Du J, Li H, Cao Z, Cheng Z, Wang Z.   +5 more
europepmc   +2 more sources

Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

MedComm, 2023
As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size.
Liemei Lv, Xiangxiang Zhou
doaj   +1 more source

White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki To Promote Its Infection in Penaeus vannamei

Microbiology Spectrum, 2023
White spot syndrome virus (WSSV) is a serious threat to shrimp aquaculture, especially Pacific white shrimp, Penaeus vannamei, the most farmed shrimp in the world.
Linwei Yang, Zi-Ang Wang, Ran Geng, Hengwei Deng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu   +8 more
doaj   +1 more source

A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration

Frontiers in Cell and Developmental Biology, 2020
Alzheimer's disease (AD, OMIM: 104300) is an age-related disorder that affects millions of people. One of the underlying causes of AD is generation of hydrophobic amyloid-beta 42 (Aβ42) peptides that accumulate to form amyloid plaques.
Madison Irwin, Meghana Tare, Aditi Singh, Oorvashi Roy Puli, Neha Gogia, Matthew Riccetti, Prajakta Deshpande, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh   +15 more
doaj   +1 more source

Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

eLife, 2020
Tissue homeostasis and regeneration in the Drosophila midgut is regulated by a diverse array of signaling pathways including the Hippo pathway. Hippo signaling restricts intestinal stem cell (ISC) proliferation by sequestering the transcription co-factor
Xue Hao, Shimin Wang, Yi Lu, Wentao Yu, Pengyue Li, Dan Jiang, Tong Guo, Mengjie Li, Jinhui Li, Jinjin Xu, Wenqing Wu, Margaret S Ho, Lei Zhang   +12 more
doaj   +1 more source

The critical role of the Hippo signaling pathway in kidney diseases

Frontiers in Pharmacology, 2022
The Hippo signaling pathway is involved in cell growth, proliferation, and apoptosis, and it plays a key role in regulating organ size, tissue regeneration, and tumor development.
Yuting Sun, De Jin, Ziwei Zhang, Di Jin, JiaoJiao Xue, LiYun Duan, YuQing Zhang, XiaoMin Kang, FengMei Lian, FengMei Lian   +9 more
doaj   +1 more source

Histone Acetylation-Mediated Regulation of the Hippo Pathway [PDF]

, 2013
The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment.
A Rebbaa, A Salic, Abdelhadi Rebbaa, Ali J. Marian, B Zhao, B Zhao, BL Mirkin, BR Mardin, BS Robinson, C Alarcon, C Zhang, CA Thorne, D Basu, D Lai, Dipanjan Basu, E Miller, E Pazolli, F Chu, F Kanai, F Martin-Belmonte, FA Grusche, FX Yu, G Halder, H Oh, H Oh, HH Cho, HJ Chen, HM Prince, I Lian, J Avruch, J Zhang, JP Lyons, K Harvey, KF Harvey, KF Harvey, L Azzolin, L Zender, L Zhao, LM McCaffrey, M Cordenonsi, M Sudol, MA St John, Miguel Reyes-Múgica, NA Grzeschik, QY Lei, RS Udan, S Wu, SA Mousa, T de Cristofaro, T Xu, W Huang, WM Konsavage Jr, X Varelas, X Varelas, XJ Li, Y Hao, Y Liu, Y Wang, Z Zhou   +58 more
core   +6 more sources

Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing

Cell Regeneration, 2023
The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng, Ximei Wu   +7 more
doaj   +1 more source