Results 91 to 100 of about 990,791 (254)

LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p/MARK4/Hippo signaling pathway

Journal of experimental & clinical cancer research : CR, 2019
An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing ...
Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu, D. Pang   +7 more
semanticscholar   +1 more source

Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis

Cancers, 2020
The Hippo pathway plays a critical role in tissue and organ growth under normal physiological conditions, and its dysregulation in malignant growth has made it an attractive target for therapeutic intervention in the fight against cancer.
Taha Azad, Reza Rezaei, Abera Surendran, R. Singaravelu, Stephen Boulton, Jaahnavi Dave, J. Bell, C. Ilkow   +7 more
semanticscholar   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

Journal of Translational Medicine
Background First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activity regulates YAP and TAZ final
Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon, Marcello Maugeri-Saccà   +9 more
doaj   +1 more source

The Hippo Signaling Pathway in Pancreatic Cancer

Anticancer Research, 2019
Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer.
D. Ansari, Henrik Ohlsson, Carl Althini, Monika Bauden, Qimin Zhou, D. Hu, R. Andersson   +6 more
semanticscholar   +1 more source

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases

Journal of Immunology Research, 2018
Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease ...
Wenyi Zhou, Mingyi Zhao
doaj   +1 more source

The Hippo Signaling Pathway in Cardiac Development and Diseases

Front. Cell Dev. Biol., 2019
Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity.
Masum M. Mia, Manvendra K. Singh
semanticscholar   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Knockdown of lncRNA LEF1-AS1 inhibited the progression of oral squamous cell carcinoma (OSCC) via Hippo signaling pathway

Cancer Biology & Therapy, 2019
It is verified that long non-coding RNAs (lncRNAs) play crucial roles in various cancers. LncRNA LEF1-AS1 is a reported oncogene in colorectal cancer and glioblastoma.
Chanqiong Zhang, C. Bao, Xiuxing Zhang, Xinshi Lin, D. Pan, Yangzong Chen   +5 more
semanticscholar   +1 more source