Results 131 to 140 of about 33,422 (243)

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

Medicinal Research Reviews, EarlyView.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He, Patrick Connerty, Antoine de Weck   +2 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Strategies for Assessing Post‐Wildfire Geomorphic Resilience in Semiarid Rivers

River Research and Applications, EarlyView.
ABSTRACT We review and summarize diverse components of a catchment that can be monitored after wildfire to assess the geomorphic resilience of the river corridor in semiarid regions. We distinguish upland portions of river catchments from river corridors.
Ellen Wohl, Shayla Triantafillou, Alex Thornton‐Dunwoody, Connor Mertz, Katie Larkin, William Keenan, Steven Griffin, Dylan Davis, Lindsey Blehm   +8 more
wiley   +1 more source

Contrasting properties of predation and scavenging networks governed by megaherbivores in an African savannah

Journal of Animal Ecology, EarlyView.
For the first time, predation and scavenging networks are directly compared within a single ecosystem. Using an 8‐year dataset of African mammals, including megaherbivores, this study reveals distinct structural rules and body mass constraints, providing a scalable framework for studying consumer–resource dynamics and ecosystem function.
Solange Alexandra Batista‐Nunes, Esther Sebastián‐González, Femke Broekhuis, Frank van Langevelde, Niels Mogensen, Marcos Moleón   +5 more
wiley   +1 more source

Sensory Biology of the Franciscana (Pontoporia blainvillei, Pontoporiidae, Cetartiodactyla): Ontogenetic Modifications of Vibrissae and Vibrissal Crypts

Integrative Zoology, EarlyView.
The transition of cetaceans from a terrestrial to an aquatic environment involved a crucial sensory adaptation to environments with limited visibility. Vibrissae, important mechanoreceptors, undergo an ontogenetic transformation in odontocetes. This research describes the histomorphology of vibrissae and crypts at different developmental stages ...
Cecilia Mariana Krmpotic, Cleopatra Mara Loza, Alejo Carlos Scarano, Pedro Fernando Andrés‐Laube, Francisco Acuña, Juan Pablo Loureiro, Carolina Natalia Zanuzzi, Nicolás Nahuel Castro, María Teresa Pombo, Lorenzo von Fersen, Claudio Gustavo Barbeito   +10 more
wiley   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway. [PDF]

Biochem Biophys Rep
Ma T, Yu Y, Yang S, Xiao Q, Zuo X, Wei G, Chen Y.   +6 more
europepmc   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Correction: The impact of inhibiting the Hippo signaling pathway effector molecule YAP1 on in vitro glioblastoma and glioblastoma stem cells. [PDF]

Sci Rep
Ozates NP, Bagca BG, Asik A, Gunduz C, Akin H, Avci CB.   +5 more
europepmc   +1 more source