Results 81 to 90 of about 101,099 (274)

Exploring adult hippocampal neurogenesis using optogenetics [PDF]

, 2018
In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core  

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

D-serine increases adult hippocampal neurogenesis [PDF]

Frontiers in Neuroscience, 2013
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes.
Sultan Sebastien, Gebara Elias G, Moullec Kristell, Toni Nicolas   +3 more
openaire   +5 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?

Neurobiology of Disease, 2022
Temporal lobe epilepsy (TLE) is a neurological disorder affecting millions of people worldwide and currently represents the most common form of focal epilepsy.
Sebastian Dohm-Hansen, Francisco Donoso, Paul J. Lucassen, Gerard Clarke, Yvonne M. Nolan   +4 more
doaj   +1 more source

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain [PDF]

, 2012
Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes.
A Kitamura, AA Willette, AH Miller, AL Jefferson, AL Marsland, AL Sousa, American Psychiatric Association, Astrid V Rauch, AT Beck, B Balasubramaniam, B Viviani, Bernhard T Baune, BL Pierce, BT Baune, BT Baune, Carsten Konrad, CF Terry, Christina Uhlmann, CS Carlson, Dominik Grotegerd, E Brietzke, E Halperin, E Vermetten, Eva Birosova, F Faul, GM MacQueen, H Tilg, H-U Wittchen, Harald Kugel, I HapMap, I Hickie, I Morales, J Ashburner, J Hannestad, J McAfoose, J Oh, JA Wagner, JE Malberg, JM Gatt, JM Kim, Jochen Bauer, JP Godbout, K Kasai, K Pham, Katharina Domschke, KK Bowen, L Capuron, L Christiansen, L Vallieres, L Vitkovic, LD Ward, M Bonafe, M Murphy, M Pickering, M Yamada, MA Kahn, MA Munoz-Fernandez, MK Kang, ML Monje, MT Heneka, N Ohbayashi, N Pervaiz, N Raz, N Tzourio-Mazoyer, O Davidovich, O Islam, P Angelopoulos, P Oeth, P Videbech, Patricia Ohrmann, RA Gadient, RA Gadient, RM Thomas, S Campbell, S Eickhoff, S Ihara, S Ihara, S Lehrl, S Matsuda, S Toulmond, SA Loddick, SD Forman, Sonja Schöning, T Beblo, T Frodl, T Hama, T Hama, T Hirano, Thomas Suslow, U Dannlowski, Udo Dannlowski, V Tancredi, Volker Arolt, Walter Heindel, Y Akaneya, Y Dowlati, Y Kushima, Y Kushima, YP Peng, YY Wu   +99 more
core   +3 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis

Cells, 2023
Zinc is highly concentrated in synaptic vesicles throughout the mammalian telencephalon and, in particular, the hippocampal dentate gyrus. A role for zinc in modulating synaptic plasticity has been inferred, but whether zinc has a particular role in ...
Michael J. Chrusch, Selena Fu, Simon C. Spanswick, Haley A. Vecchiarelli, Payal P. Patel, Matthew N. Hill, Richard H. Dyck   +6 more
doaj   +1 more source

Working memory learning method and astrocytes number in different subfields of rat's Hippocampus [PDF]

, 2008
The aim of this study was evaluation of the astrocytes number in different subfields of rat's Hippocampus after spatial learning with usage of Morris Water Maze technique and working memory method.
Abbas, P., Ahmad, H., Mehrdad, J., Naser, N., Yousef, S.   +4 more
core   +1 more source