Results 1 to 10 of about 620,156 (317)
Hippocampal place cell sequences differ during correct and error trials in a spatial memory task
Nature Communications, 2021 Here the authors compare place cell sequence coding during correct and error trials in a spatial memory task. Sequences coded paths that were longer and more temporally compressed during correct trials and developed a bias to replay paths to a goal ...
Chenguang Zheng +3 more
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Translational Psychiatry, 2023 ANK3 is a leading bipolar disorder (BD) candidate gene in humans and provides a unique opportunity for studying epilepsy-BD comorbidity. Previous studies showed that deletion of Ank3-1b, a BD-associated variant of Ank3 in mice leads to increased firing ...
Juan E. Villacres +5 more
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Nature Communications, 2020 Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.
Ping-Chieh Pao +17 more
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Journal of Biomedical Science, 2021 Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function.
Ping-Chieh Pao, Li-Huei Tsai
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eLife, 2017 Simultaneous stimulation of the antennal lobes (ALs) and the ascending fibers of the ventral nerve cord (AFV), two sensory inputs to the mushroom bodies (MBs), induces long-term enhancement (LTE) of subsequent AL-evoked MB responses.
Kohei Ueno +5 more
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Interleukin-6 deficiency exacerbates Huntington’s disease model phenotypes
Molecular Neurodegeneration, 2020 Huntington’s disease (HD) is an incurable neurodegenerative disorder caused by CAG trinucleotide expansions in the huntingtin gene. Markers of both systemic and CNS immune activation and inflammation have been widely noted in HD and mouse models of HD ...
Mary H. Wertz +5 more
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Cell Reports, 2017 The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer’s disease (AD) patients and mouse models.
Hidekuni Yamakawa +9 more
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Cingulate-motor circuits update rule representations for sequential choice decisions
Nature Communications, 2022 The anterior cingulate cortex allows an animal to update its behaviour when the environment changes. In this work, the authors identify a pathway from cingulate to secondary motor cortex, critical for updating motor rules following behavioural errors.
Daigo Takeuchi +8 more
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Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Frontiers in Behavioral Neuroscience, 2014 Many psychiatric illnesses are characterized by deficits in the social domain. For example, there is a high rate of co-morbidity between autism spectrum disorders and anxiety disorders.
Stephen Azariah Allsop +4 more
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Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
Nature Communications, 2020 The neural circuit mechanisms for sensorimotor control by the prefrontal cortex (PFC) are unclear. Here, the authors show that PFC outputs to the visual cortex and superior colliculus respectively facilitate sensory processing and action selection ...
Rafiq Huda +9 more
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