Results 41 to 50 of about 620,156 (317)

Dietary Protein Intake and Peritoneal Protein Losses in Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) patients lose protein in their waste dialysate, potentially increasing their risk for malnutrition. We wished to determine whether there was any association between losses and dietary protein intake (DPI). Methods DPI was assessed from 24‐h dietary recall using Nutrics software.
Haalah Shaaker, Andrew Davenport
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties

Nature Communications, 2016
Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to ...
Sarah A. Wolfe, Emily R. Workman, Chelcie F. Heaney, Farr Niere, Sanjeev Namjoshi, Luisa P. Cacheaux, Sean P. Farris, Michael R. Drew, Boris V. Zemelman, R. Adron Harris, Kimberly F. Raab-Graham   +10 more
doaj   +1 more source

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

Cell Reports, 2012
Despite extensive research into both synaptic and morphological changes, surprisingly little is known about dendritic function in fragile X syndrome (FXS).
Darrin H. Brager, Arvin R. Akhavan, Daniel Johnston   +2 more
doaj   +1 more source

Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2023
Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal
Jenna N. Adams, Freddie Márquez, Myra S. Larson, John T. Janecek, Blake A. Miranda, Jessica A. Noche, Lisa Taylor, Martina K. Hollearn, Liv McMillan, David B. Keator, Elizabeth Head, Robert A. Rissman, Michael A. Yassa   +12 more
doaj   +1 more source

Effects of alcohol on subjective ratings of prospective and everyday memory deficits [PDF]

, 2003
Background: Research has shown that heavy alcohol use has a detrimental effect on retrospective memory. Less is known about the effect of alcohol on everyday memory.
Buchanan, Tom, Scholey, Andrew, Parrott, A.C., Ling, J., Heffernan, Tom, Heffernan, T.M., Parrott, Andrew, Rodgers, J., Scholey, A.B., Ling, Jonathan, Rodgers, Jacqui, Buchanan, T.   +11 more
core   +1 more source

Chemosensory learning and memory [PDF]

Frontiers in Systems Neuroscience, 2012
The aim of this issue is to present an updated view of present knowledge and questions raised in the rapidly expanding field of chemosensory (taste and olfactory) learning. Taste is a powerful primary (unlearned) reinforcer, and topics such as olfactory-taste and visual taste association learning are covered in this issue.
Gallo, Milagros, Rolls, Edmund
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats [PDF]

Advanced Pharmaceutical Bulletin, 2014
Purpose: Chronic stress has been reported to induce oxidative damage of the brain. A few studies have shown that Crocus Sativus L., commonly known as saffron and its active constituent crocin may have a protective effect against oxidative stress.
Ahmad Reza Bandegi, Ali Rashidy-Pour, Abbas Ali Vafaei, Behshid Ghadrdoost   +3 more
doaj   +1 more source