Results 61 to 70 of about 620,156 (317)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases

Molecular Neurodegeneration
Many diseases and disorders of the nervous system suffer from a lack of adequate therapeutics to halt or slow disease progression, and to this day, no cure exists for any of the fatal neurodegenerative diseases.
Francisco J. Garcia, Myriam Heiman
doaj   +1 more source

Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

Nature Communications, 2018
Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Tawnie K. Silva, Elaine Lu, Ximiao Wen, Panayiota Poirazi, Joshua T. Trachtenberg, Alcino J. Silva   +10 more
doaj   +1 more source

Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala

Cell Reports, 2018
The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc ...
Anna Beyeler, Chia-Jung Chang, Margaux Silvestre, Clémentine Lévêque, Praneeth Namburi, Craig P. Wildes, Kay M. Tye   +6 more
doaj   +1 more source

Algebraic approach for subspace decomposition and clustering of neural activity

STAR Protocols, 2022
Summary: We developed an approach to decompose neuronal signals into disjoint components, corresponding to task- or event-based epochs. This protocol describes how to project behavioral templates onto a low-dimensional subspace of neuronal responses to ...
Elie M. Adam, Mriganka Sur
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The emergence of molecular systems neuroscience

Molecular Brain, 2022
Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain states and behavior.
Yang Shen, Alessandro Luchetti, Giselle Fernandes, Won Do Heo, Alcino J. Silva   +4 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice

Nature Communications
Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes.
Daniela Rodrigues-Amorim, P. Lorenzo Bozzelli, TaeHyun Kim, Liwang Liu, Oliver Gibson, Cheng-Yi Yang, Mitchell H. Murdock, Fabiola Galiana-Melendez, Brooke Schatz, Alexis Davison, Md Rezaul Islam, Dong Shin Park, Ravikiran M. Raju, Fatema Abdurrob, Alissa J. Nelson, Jian Min Ren, Vicky Yang, Matthew P. Stokes, Li-Huei Tsai   +18 more
doaj   +1 more source

Hippocampal network activity is transiently altered by induction of long-term potentiation in the dentate gyrus of freely behaving rats

Frontiers in Behavioral Neuroscience, 2007
A role for oscillatory activity in hippocampal neuronal networks has been proposed in sensory encoding, cognitive functions and synaptic plasticity.
Arthur Bikbaev, Denise Manahan-Vaughan, Denise Manahan-Vaughan   +2 more
doaj   +1 more source