Results 61 to 70 of about 804,912 (360)

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats

Frontiers in Neuroscience, 2019
Alzheimer’s disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal ...
Yulia V. Dobryakova, Maria N. Volobueva, Anna O. Manolova, Tatiana M. Medvedeva, Alexey A. Kvichansky, Natalia V. Gulyaeva, Vlamidir A. Markevich, Mikhail Yu. Stepanichev, Alexey P. Bolshakov, Alexey P. Bolshakov   +9 more
doaj   +1 more source

Dorsal-Ventral Differences in Modulation of Synaptic Transmission in the Hippocampus

Frontiers in Synaptic Neuroscience, 2020
Functional diversification along the longitudinal axis of the hippocampus is a rapidly growing concept. Modulation of synaptic transmission by neurotransmitter receptors may importantly contribute to specialization of local intrinsic network function ...
George Trompoukis, Costas Papatheodoropoulos   +1 more
doaj   +1 more source

Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery

NeuroImage: Clinical, 2021
Objective: To explore the structural and functional reorganization of contralateral hippocampus in patients with unilateral mesial temporal lobe epilepsy (mTLE) who achieved seizure-freedom after anterior temporal lobectomy (ATL).
Wei Li, Yuchao Jiang, Yingjie Qin, Baiwan Zhou, Du Lei, Heng Zhang, Ding Lei, Dezhong Yao, Cheng Luo, Qiyong Gong, Dong Zhou, Dongmei An   +11 more
doaj   +1 more source

Altered hippocampal function in major depression despite intact structure and resting perfusion [PDF]

, 2016
Background: Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear.
A. Finkelmeyer, Campbell, Della Sala, Golden, I. N. Ferrier, J. He, J. J. Maller, J. Nilsson, K. Coventry, L. Stevens, McKinnon, Nelson, P. Gallagher, R. A. Moss, R. H. McAllister-Williams, S. Small, Schmidt, Sheehan, Spielberger   +18 more
core   +2 more sources

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Structural imaging biomarkers of sudden unexpected death in epilepsy. [PDF]

, 2015
Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially attributable to sudden death pathogenesis were present on magnetic resonance imaging in people who ...
Balestrini, Simona, Diehl, Beate, Duncan, John S, Harper, Ronald M, Koepp, Matthias, Lhatoo, Samden, Micallef, Caroline, Sander, Josemir W, Scott, Catherine, Sisodiya, Sanjay M, Thom, Maria, Vos, Sjoerd B, Wandschneider, Britta   +12 more
core   +3 more sources

Protective Effects of Wheat Sprout on Acrylamide Toxicity in the Hippocampus Structure and Spatial Learning and Memory of Rat [PDF]

, 2023
Hamid Reza Moradi, Mahnaz Taherianfard, Mohsen Rashidi, Zahra Javid, Sayed Amir Hesami   +4 more
openalex   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source