Results 151 to 160 of about 310,272 (392)

Population Pharmacokinetics of Fruquintinib, a Selective Oral Inhibitor of VEGFR ‐1, ‐2, and ‐3, in Patients with Refractory Metastatic Colorectal Cancer

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Fruquintinib is a selective, oral tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors 1, 2, and 3, which is approved for patients with previously treated metastatic colorectal cancer regardless of biomarker status. This population pharmacokinetic (PK) analysis characterized sources of interpatient variability on
Xiaofei Zhou   +10 more
wiley   +1 more source

Exogenous Histamine Stimulates Colorectal Cancer Implant Growth via Immunosuppression in Mice

open access: yesJournal of Pharmacological Sciences, 2005
Results from a limited number of studies suggest a potential role for endogenous histamine in regulating tumor growth in immunocompetent cells. The present study examined the effects of exogenous histamine on colorectal cancer growth and the immune ...
Kazuyoshi Tomita, Susumu Okabe
doaj  

EFFECT OF HISTAMINE ON GANGLIONIC TRANSMISSION [PDF]

open access: bronze, 1959
Sheldon B. Gertner, Robert Kohn
openalex   +1 more source

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

open access: yesChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas   +4 more
wiley   +1 more source

Incidence of symptomatic Covid‐19 infections in patients with mastocytosis and chronic myeloid leukemia: A comparison with the general Austrian population

open access: yesEuropean Journal of Haematology, Volume 110, Issue 1, Page 67-76, January 2023., 2023
Abstract Background The SARS‐COV‐2 (Covid‐19) pandemic has impacted the management of patients with hematologic disorders. In some entities, an increased risk for Covid‐19 infections was reported, whereas others including chronic myeloid leukemia (CML) had a lower mortality.
Irene Graf   +7 more
wiley   +1 more source

Chronic eosinophilic granulomatous tenosynovitis in a Quarter Horse mare

open access: yesEquine Veterinary Education, Volume 35, Issue 2, Page e91-e97, February 2023., 2023
Summary A 5‐year‐old Quarter Horse mare was presented to the Michigan State University Equine Surgery Service for evaluation of a right hind metatarsophalangeal joint injury. On presentation, the horse was a grade 4/5 lame. Radiographs and ultrasonography showed peritendinous ossification/mineralisation of soft tissue structures and digital flexor ...
Zoë J. Williams   +2 more
wiley   +1 more source

Central Effect of Exogenous Histamine on Pain Induced by Sub-Plantar Injection of Formalin in Rabbits [PDF]

open access: yesVeterinary Research Forum, 2010
In the present study, the effects of intracerebroventricular (ICV) administration of normal saline (control), histamine, mepyramine (a histamine H1-receptor antagonist) and ranitidine (a histamine H2-receptor antagonist) were investigated on the formalin-
Esmaeal Tamaddonfard
doaj  

Influence of Cosolvents on the Pressure Stability of Human Serum Albumin

open access: yesphysica status solidi (a), EarlyView.
Human serum albumin is able to bind various hydrophobic substances and drugs. To investigate this interaction, the protein structure is analyzed using small‐angle X‐ray scattering under high hydrostatic pressure. The resulting radius of gyration (see picture) indicates that hydrophobic substances influence the pressure stability of HSA differently ...
Jaqueline Savelkouls   +3 more
wiley   +1 more source

Can contagious itch be affected by positive and negative suggestions?

open access: yesExperimental Dermatology, Volume 31, Issue 12, Page 1853-1862, December 2022., 2022
Abstract Contagious itch can be evoked by observing people scratching. Verbal suggestions about to‐be‐received itch can influence itch intensity, as shown by placebo research, but it is unknown whether this extends to contagious itch. The current study aimed to replicate prior findings that listening to scratching and rubbing sounds elicits contagious ...
Stefanie H. Meeuwis   +4 more
wiley   +1 more source

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