Results 241 to 250 of about 53,301 (333)

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Histamine regulates the activity and the expression of the Na⁺/H⁺ exchanger (NHE)3 in human epithelial HK-2 cells. [PDF]

Inflamm Res
Gerbino C, Foglietta F, Corsi D, Nardini P, Cangemi L, Benetti E, Rosa AC.   +6 more
europepmc   +1 more source

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

The Histamine-Associated Inflammatory Landscape of Endometriosis: Molecular Profiling of HDC, HRH1-HRH4, and Cytokines Across Lesion Subtypes. [PDF]

Int J Mol Sci
Velho RV, Freitag JH, Brueckner AM, Thalmeier L, Pohl J, Mechsner S.   +5 more
europepmc   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Advances in the treatment of malignant tumors with neurological drugs. [PDF]

Discov Oncol
Li Y, Na J, Zhong L, Zhao Y.
europepmc   +1 more source

The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Plant trichomes are not just simple hairs but metabolic powerhouses shaped by complex genetic programs. While the MYB‐bHLH‐WD40 module is well studied in Arabidopsis, recent findings reveal that HD‐Zip IV transcription factors drive multicellular and glandular trichome development through dose‐dependent mechanisms.
Meng Li, Yuanbo Huang, Yadi Du, Shuang Wu   +3 more
wiley   +1 more source

Evaluation of the Antihistamine and Anti-Inflammatory Effects of a Nutraceutical Blend Based on Quercetin, <i>Perilla frutescens</i>, <i>Boswellia serrata</i>, <i>Blackcurrant</i>, <i>Parthenium</i>, <i>Helichrysum</i>, <i>Lactobacillus acidophilus</i> and <i>Bifidobacterium animalis</i> Through In Vitro and In Vivo Approaches-Preliminary Data. [PDF]

Curr Issues Mol Biol
Masieri S, Frati F, Torello G, Colasante M, Scquizzato M, Cavaliere C.   +5 more
europepmc   +1 more source

Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley   +1 more source

TRPV4 Promotes Histamine Receptor Signaling in Lymphatic Endothelial Cells

Retamal JS, Peng S, Nguyen T, Bandala-Sanchez E, Eriksson EM, McCague RE, Mahdavian NS, Carbone SE, Cao E, Gondin AB, Veldhuis NA, Poole DP.   +11 more
europepmc   +1 more source