Results 21 to 30 of about 53,301 (333)

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

Frontiers in Pharmacology, 2022
Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized that
Ibrahim Alrashdi, Ibrahim Alrashdi, Amal Alsubaiyel, Amal Alsubaiyel, Michele Chan, Michele Chan, Emma E. Battell, Abdel Ennaceur, Miles A. Nunn, Wayne Weston-Davies, Paul L. Chazot, Ilona Obara, Ilona Obara   +12 more
doaj   +1 more source

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]

, 2017
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S, Kim, Bo-Mi, Kim, Hae-Rim, Kim, Kyoung-Woon, Lee, Kyung-Ann, Lee, Sang-Heon   +5 more
core   +1 more source

Effects of an H3R Antagonist on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid [PDF]

, 2015
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders primarily characterized by impaired social interaction and communication, and by restricted repetitive behaviors and interests.
A Burban, AL Christianson, BA Ellenbroek, C Ito, Carmem Gottfried, CK da Silveira, D Farzin, DD Zhang, Diego Baronio, E Tiligada, E Trofimiuk, F Happé, FI Roullet, G Griebel, G Huguet, Gabriela Mueller de Melo, GB Fox, Gustavo Della Flora Nunes, HG Martin, HL Haas, JA Saunders, JC Schwartz, JD Brioni, JS Noland, JW Brown, Kamila Castro, L Huang, L Shan, LA Linday, LA Linday, LS Carroll, M Motawaj, MB Passani, MM Konstantareas, Nouchine Hadjikhani, P Malmberg-Aiello, P Paschou, PG Rossi, PM Rodier, R Ferstl, R Kaminsky, RL Bromley, Rudimar Riesgo, S Nuutinen, SD Glick, SD Steele, Silvestrin R Bristot, SM Owen, T Schneider, T Suzuki, Taylor Gonchoroski, V Bambini-Junior, Victorio Bambini-Junior, VV Joshi   +53 more
core   +12 more sources

Histamine and Delirium: Current Opinion

Frontiers in Pharmacology, 2019
Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention ...
Paul L. Chazot, Laura Johnston, Edel Mcauley, Stephen Bonner   +3 more
doaj   +1 more source

Pitolisant and Other Histamine-3 Receptor Antagonists—An Update on Therapeutic Potentials and Clinical Prospects

Medicines, 2020
Background: Besides its well-known role as a peripheral chemical mediator of immune, vascular, and cellular responses, histamine plays major roles in the central nervous system, particularly in the mediation of arousal and cognition-enhancement.
Victoria Harwell, Pius S. Fasinu
doaj   +1 more source

Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms [PDF]

, 2012
Although large cholangiocytes exert their functions by activation of cyclic adenosine 3',5'-monophosphate (cAMP), Ca(2+)-dependent signaling regulates the function of small cholangiocytes. Histamine interacts with four receptors, H1-H4HRs.
Fanyin Meng, FRANCHITTO, Antonio, GAUDIO, EUGENIO, Gianfranco D. Alpini, Guido Carpino, Hannah E. Shine, Heather L. Francis, Julie K. Venter, Kimberly K. Baker, MANCINELLI, ROMINA, Mellanie A. White, ONORI, PAOLO, RENZI, ANASTASIA, Sharon Demorrow, Taylor C. Francis, Yoshiyuki Ueno   +15 more
core   +1 more source

Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]

, 2007
Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma, Kennedy, Charles, Tasker, Paul N., Westfall, Timothy D.   +3 more
core   +1 more source

Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]

, 2013
The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto, Fernández, Natalia Brenda, Fitzsimons, Carlos, Monczor, Federico, Shayo, Carina Claudia   +4 more
core   +9 more sources

Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy

Life
Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders.
Erwen Kou, Xiaobei Zhang, Baiping Dong, Bo Wang, Yuanjie Zhu   +4 more
doaj   +1 more source

Theoretical surgery: a new specialty in operative medicine [PDF]

, 1989
Theoretical surgery is defined as a nonoperative decision analysis and clinical and basic research supporting system for surgery. It developed to meet the needs of academic surgeons to coordinate communication with basic science disciplines. This article
Lorenz, Wilfried, Rothmund, M.
core   +1 more source