Results 31 to 40 of about 28,885 (301)

Binding of histamine H3-receptor antagonists to hematopoietic progenitor cells Evidence for a histamine transporter unrelated to histamine H3 receptors [PDF]

, 1997
Hematopoietic progenitor cells can take up histamine or release IL-3-induced histamine through a bi-directional transport system that is blocked by H3-receptor antagonists. In the present study we demonstrate a correlation between the affinity of various
Dy, Michel, Schunack, Walter, Walter Schunack, Stark, Holger, Corbel, Stéphane, Holger Stark, Traiffort, Elisabeth, Stéphane Corbel, Elisabeth Traiffort, Michel Dy   +9 more
core   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, EarlyView.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

The dopaminergic system is able to modulate the central histamine-induced pressor effect in hemorrhage-shocked rats

Annales Academiae Medicae Silesiensis
Introduction: Histamine administered intracerebroventricularly (icv) induces a resuscitating effect in hemorrhage-shocked rats. Dopamine receptors are present in neuronal pathways involved in central cardiovascular regulation; therefore, the aim of the ...
Karolina Jasikowska, Magdalena Zając, Alessandra Ottani, Daniela Giuliani , Salvatore Guarini, Jerzy Jochem   +5 more
doaj   +1 more source

Histamine and Skin Barrier: Are Histamine Antagonists Useful for the Prevention or Treatment of Atopic Dermatitis? [PDF]

J Clin Med, 2015
Atopic Dermatitis (AD), the most common chronic inflammatory skin disease, is characterized by an overactive immune response to a host of environmental allergens and dry, itchy skin.
De Benedetto A, Yoshida T, Fridy S, Park JE, Kuo IH, Beck LA.   +5 more
europepmc   +2 more sources

Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

Stem Cell Research & Therapy, 2020
Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification.
Xiaowei Zhu, Suling Ding, Hui Li, Zhiwei Zhang, Lili Xu, Jian Wu, Xiangfei Wang, Yunzeng Zou, Xiangdong Yang, Junbo Ge   +9 more
doaj   +1 more source

Targeted therapy with histamine antagonists - New challenges to fight with breast cancer

Journal of Education, Health and Sport, 2022
Breast cancer (BC) is currently the most commonly diagnosed cancer in women. BC is most often derived from the epithelial tissue of the mammary gland and is a global problem due to the steady increase in morbidity and mortality in most countries.
Piotr Jan Więsyk, Paulina Oleksa, Zuzanna Chilimoniuk, Maciej Dobosz, Maciej Sobczyk, Małgorzata Słaboń   +5 more
doaj   +1 more source

Effects of histamine and its receptor antagonists on peritoneal permeability [PDF]

, 1988
Effects of histamine and its receptor antagonists on peritoneal permeability. Peritoneal fluid and mass transfer rates were studied in rabbits undergoing control dialyses and dialyses with intraperitoneal histamine, or its receptor antagonists alone or ...
Shostak, Avshalom, Maher, John F., Chakrabarti, Eva, Hirszel, Przemyslaw   +3 more
core   +1 more source

Role of Histamine and Related Signaling in Kaposi’s Sarcoma-Associated Herpesvirus Pathogenesis and Oncogenesis

Viruses, 2023
Although Kaposi’s sarcoma-associated herpesvirus (KSHV) has been reported to cause several human cancers including Kaposi’s sarcoma (KS) and primary effusion lymphoma (PEL), the mechanisms of KSHV-induced tumorigenesis, especially virus–host interaction ...
Jungang Chen, Jiao Song, Karlie Plaisance-Bonstaff, Shengyu Mu, Steven R. Post, Lu Dai, Zhiqiang Qin   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze [PDF]

, 2012
The role of the histamine H3 receptor (H3R) in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests used in previous studies. In the present report, we describe two experiments.
Paul L. Chazot, Lethbridge, Natasha L., Ruan van Rensburg, Chazot, Paul L., Rushdie M. A. Abuhamdah, Abdel Ennaceur, Abuhamdah, Rushdie M., Natasha L. Lethbridge, van Rensburg, Ruan, Ennaceur, Abdelkader   +9 more
core   +1 more source